E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)
1_MECPS 6_ CQHVS 11_ KEETP 16_ KFCSQ 21_ CGERL 26_ PPAAP 31_ IADSE 36_ NNNST 41_ MASAS 46_ EGEME 51_ CGQEL 56_ KEEGG 61_ PCLFP 66_ GSDSW 71_ QENPE 76_ EPCSK 81_ ASWTV 86_ QESKK 91_ KKRKK 96_ KKKGN 101_ KSASS 106_ ELASL 111_ PLSPA 116_ SPCHL 121_ TLLSN 126_ PWPQD 131_ TALPH 136_ SQAQQ 141_ SGPTG 146_ QPSQP 151_ PGTAT 156_ TPLEG 161_ DGLSA 166_ PTEVG 171_ DSPLQ 176_ AQALG 181_ EAGVA 186_ TGSEA 191_ QSSPQ 196_ FQDHT 201_ EGEDQ 206_ DASIP 211_ SGGRG 216_ LSQEG 221_ TGPPT 226_ SAGEG 231_ HSRTE 236_ DAAQE 241_ LLLPE 246_ SKGGS 251_ SEPGT 256_ ELQTT 261_ EQQAG 266_ ASASM 271_ AVDAV 276_ AEPAN 281_ AVKGA 286_ GKEMK 291_ EKTQR 296_ MKQPP 301_ ATTPP 306_ FKTHC 311_ QEAET 316_ KTKDE 321_ MAAAE 326_ EKVGK 331_ NEQGE 336_ PEDLK 341_ KPEGK 346_ NRSAA 351_ AVKNE 356_ KEQKN 361_ QEADV 366_ QEVKA 371_ STLSP 376_ GGGVT 381_ VFFHA 386_ IISLH 391_ FPFNP 396_ DLHKV 401_ FIRGG 406_ EEFGE 411_ SKWDS 416_ NICEL 421_ HYTRD 426_ LGHDR 431_ VLVEG 436_ IVCIS 441_ KKHLD 446_ KYIPY 451_ KYVIY 456_ NGESF 461_ EYEFI 466_ YKHQQ 471_ KKGEY 476_ VNRCL 481_ FIKSS 486_ LLGSG 491_ DWHQY 496_ YDIVY 501_ MKPHG 506_ RLQKV 511_ MNHIT 516_ DGPRK 521_ DLVKG 526_ KQIAA 531_ ALMLD 536_ STFSI 541_ LQTWD 546_ TINLN 551_ SFFTQ 556_ FEQFC 561_ FVLQQ 566_ PMIYE 571_ GQAQL 576_ WTDLQ 581_ YREKE 586_ VKRYL 591_ WQHLK 596_ KHVVP 601_ LPDGK 606_ STDFL 611_ PVDCP 616_ VRSKL 621_ KTGLI 626_ VLFVV 631_ EKIEL 636_ LLEGS 641_ LDWLC 646_ HLLTS 651_ DASSP 656_ DEFHR 661_ DLSHI 666_ LGIPQ 671_ SWRLY 676_ LVNLC 681_ QRCMD 686_ TRTYT 691_ WLGAL 696_ PVLHC 701_ CMELA 706_ PRHKD 711_ AWRQP 716_ EDTWA 721_ ALEGL 726_ SFSPF 731_ REQML 736_ DTSSL 741_ LQFMR 746_ EKQHL 751_ LSIDE 756_ PLFRS 761_ WFSLL 766_ PLSHL 771_ VMYME 776_ NFIEH 781_ LGRFP 786_ AHILD 791_ CLSGI 796_ YYRLP 801_ GLEQV 806_ LNTQD 811_ VQDVQ 816_ NVQNI 821_ LEMLL 826_ RLLDT 831_ YRDKI 836_ PEEAL 841_ SPSYL 846_ TVCLK 851_ LHEAI 856_ CSSTK 861_ LLKFY 866_ ELPAL 871_ SAEIV 876_ CRMIR 881_ LLSLV 886_ DSAGQ 891_ RDETG 896_ NNSVQ 901_ TVFQG 906_ TLAAT 911_ KRWLR 916_ EVFTK 921_ NMLTS 926_ SGASF 931_ TYVKE 936_ IEVWR 941_ RLVEI 946_ QFPAE 951_ HGWKE 956_ SLLGD 961_ MEWRL 966_ TKEEP 971_ LSQIT 976_ AYCNS 981_ CWDTK 986_ GLEDS 991_ VAKTF 996_ EKCII 1001_ EAVSS 1006_ ACQSQ 1011_ TSILQ 1016_ GFSYS 1021_ DLRKF 1026_ GIVLS 1031_ AVITK 1036_ SWPRT 1041_ ADNFN 1046_ DILKH 1051_ LLTLA 1056_ DVKHV 1061_ FRLCG 1066_ TDEKI 1071_ LANVT 1076_ EDAKR 1081_ LIAVA 1086_ DSVLT 1091_ KVVGD 1096_ LLSGT 1101_ ILVGQ 1106_ LELII 1111_ KHKNQ 1116_ FLDIW 1121_ QLREK 1126_ SLSPQ 1131_ DEQCA 1136_ VEEAL 1141_ DWRRE 1146_ ELLLL 1151_ KKEKR 1156_ CVDSL 1161_ LKMCG 1166_ NVKHL 1171_ IQVDF 1176_ GVLAV 1181_ RHSQD 1186_ LSSKR 1191_ LNDTV 1196_ TVRLS 1201_ TSSNS 1206_ QRATH 1211_ YHLSS 1216_ QVQEM 1221_ AGKID 1226_ LLRDS 1231_ HIFQL 1236_ FWREA 1241_ AEPLS 1246_ EPKED 1251_ QEAAE 1256_ LLSEP 1261_ EEESE 1266_ RHILE 1271_ LEEVY 1276_ DYLYQ 1281_ PSYRK 1286_ FIKLH 1291_ QDLKS 1296_ GEVTL 1301_ AEIDV 1306_ IFKDF 1311_ VNKYT 1316_ DLDSE 1321_ LKIMC 1326_ TVDHQ 1331_ DQRDW 1336_ IKDRV 1341_ EQIKE 1346_ YHHLH 1351_ QAVHA 1356_ AKVIL 1361_ QVKES 1366_ LGLNG 1371_ DFSVL 1376_ NTLLN 1381_ FTDNF 1386_ DDFRR 1391_ ETLDQ 1396_ INQEL 1401_ IQAKK 1406_ LLQDI 1411_ SEARC 1416_ KGLQA 1421_ LSLRK 1426_ EFICW 1431_ VREAL 1436_ GGINE 1441_ LKVFV 1446_ DLASI 1451_ SAGEN 1456_ DIDVD 1461_ RVACF 1466_ HDAVQ 1471_ GYASL 1476_ LFKLD 1481_ PSVDF 1486_ SAFMK 1491_ HLKKL 1496_ WKALD 1501_ KDQYL 1506_ PRKLC 1511_ DSARN 1516_ LEWLK 1521_ TVNES 1526_ HGSVE 1531_ RSSLT 1536_ LATAI 1541_ NQRGI 1546_ YVIQA 1551_ PKGGQ 1556_ KISPD 1561_ TVLHL 1566_ ILPES 1571_ PGSHE 1576_ ESREY 1581_ SLEEV 1586_ KELLN 1591_ KLMLM 1596_ SGKKD 1601_ RNNTE 1606_ VERFS 1611_ EVFCS 1616_ VQRLS 1621_ QAFID 1626_ LHSAG 1631_ NMLFR 1636_ TWIAM 1641_ AYCSP 1646_ KQGVS 1651_ LQMDF 1656_ GLDLV 1661_ TELKE 1666_ GGDVT 1671_ ELLAA 1676_ LCRQM 1681_ EHFLD 1686_ SWKRF 1691_ VTQKR 1696_ MEHFY 1701_ LNFYT 1706_ AEQLV 1711_ YLSTE 1716_ LRKQP 1721_ PSDAA 1726_ LTMLS 1731_ FIKSN 1736_ CTLRD 1741_ VLRAS 1746_ VGCGS 1751_ EAARY 1756_ RMRRV 1761_ MEELP 1766_ LMLLS 1771_ EFSLV 1776_ DKLRI 1781_ IMEQS 1786_ MRCLP 1791_ AFLPD 1796_ CLDLE 1801_ TLGHC 1806_ LAHLA 1811_ GMGGS 1816_ PVERC 1821_ LPRGL 1826_ QVGQP 1831_ NLVVC 1836_ GHSEV 1841_ LPAAL 1846_ AVYMQ 1851_ TPSQP 1856_ LPTYD 1861_ EVLLC 1866_ TPATT 1871_ FEEVA 1876_ LLLRR 1881_ CLTLG 1886_ SLGHK 1891_ VYSLL 1896_ FADQL 1901_ SYEVA 1906_ RQAEE 1911_ LFHNL 1916_ CTQQH 1921_ REDYQ 1926_ LVMVC 1931_ DGDWE 1936_ HCYLP 1941_ SAFSQ 1946_ HKVFV 1951_ TPQAP 1956_ LEAIQ 1961_ AYLAG 1966_ HYRVP 1971_ KQTLS 1976_ AAAVF 1981_ NDRLC 1986_ VGIVA 1991_ SERAG 1996_ VGKSL 2001_ YVKRL 2006_ HDKMK 2011_ MQLNV 2016_ KNVPL 2021_ KTIRL 2026_ IDPQV 2031_ DESRV 2036_ LGALL 2041_ PFLDA 2046_ QYQKV 2051_ PVLFH 2056_ LDVTS 2061_ SVQTG 2066_ IWVFL 2071_ FKLLI 2076_ LQYLM 2081_ DINGK 2086_ MWLRN 2091_ PCHLY 2096_ IVEIL 2101_ ERRTS 2106_ VPSRS 2111_ SSALR 2116_ TRVPQ 2121_ FSFLD 2126_ IFPKV 2131_ TCRPP 2136_ KEVID 2141_ MELSA 2146_ LRSDT 2151_ EPGMD 2156_ LWEFC 2161_ SETFQ 2166_ RPYQY 2171_ LRRFN 2176_ QNQDL 2181_ DTFQY 2186_ QEGSV 2191_ EGTPE 2196_ ECLQH 2201_ FLFHC 2206_ GVINP 2211_ SWSEL 2216_ RNFAR 2221_ FLNYQ 2226_ LRDCE 2231_ ASLFC 2236_ NPSFI 2241_ GDTLR 2246_ GFKKF 2251_ VVTFM 2256_ IFMAR 2261_ DFATP 2266_ SLHTS 2271_ DQSPG 2276_ KHMVT 2281_ MDGVR 2286_ EEDLA 2291_ PFSLR 2296_ KRWES 2301_ EPHPY 2306_ VFFND 2311_ DHTTM 2316_ TFIGF 2321_ HLQPN 2326_ INGSV 2331_ DAISH 2336_ LTGKV 2341_ IKRDV 2346_ MTRDL 2351_ YQGLL 2356_ LQRVP 2361_ FNVDF 2366_ DKLPR 2371_ HKKLE 2376_ RLCLT 2381_ LGIPQ 2386_ ATDPD 2391_ KTYEL 2396_ TTDNM 2401_ LKILA 2406_ IEMRF 2411_ RCGIP 2416_ VIIMG 2421_ ETGCG 2426_ KTRLI 2431_ KFLSD 2436_ LRRGG 2441_ TNADT 2446_ IKLVK 2451_ VHGGT 2456_ TADMI 2461_ YSRVR 2466_ EAENV 2471_ AFANK 2476_ DQHQL 2481_ DTILF 2486_ FDEAN 2491_ TTEAI 2496_ SCIKE 2501_ VLCDH 2506_ MVDGQ 2511_ PLAED 2516_ SGLHI 2521_ IAACN 2526_ PYRKH 2531_ SEEMI 2536_ CRLES 2541_ AGLGY 2546_ RVSME 2551_ ETADR 2556_ LGSIP 2561_ LRQLV 2566_ YRVHA 2571_ LPPSL 2576_ IPLVW 2581_ DFGQL 2586_ SDVAE 2591_ KLYIQ 2596_ QIVQR 2601_ LVESI 2606_ SLDEN 2611_ GTRVI 2616_ TEVLC 2621_ ASQGF 2626_ MRKTE 2631_ DECSF 2636_ VSLRD 2641_ VERCV 2646_ KVFRW 2651_ FHEHS 2656_ AMLLA 2661_ QLNAF 2666_ LSKSS 2671_ VSKNH 2676_ TERDP 2681_ VLWSL 2686_ MLAIG 2691_ VCYHA 2696_ SLEKK 2701_ DSYRK 2706_ AIARF 2711_ FPKPY 2716_ DDSRL 2721_ LLDEI 2726_ TRAQD 2731_ LFLDG 2736_ VPLRK 2741_ TIAKN 2746_ LALKE 2751_ NVFMM 2756_ VVCIE 2761_ LKIPL 2766_ FLVGK 2771_ PGSSK 2776_ SLAKT 2781_ IVADA 2786_ MQGPA 2791_ AYSDL 2796_ FRSLK 2801_ QVHLV 2806_ SFQCS 2811_ PHSTP 2816_ QGIIS 2821_ TFRQC 2826_ ARFQQ 2831_ GKDLQ 2836_ QYVSV 2841_ VVLDE 2846_ VGLAE 2851_ DSPKM 2856_ PLKTL 2861_ HPLLE 2866_ DGCIE 2871_ DDPAP 2876_ HKKVG 2881_ FVGIS 2886_ NWALD 2891_ PAKMN 2896_ RGIFV 2901_ SRGSP 2906_ NETEL 2911_ IESAK 2916_ GICSS 2921_ DILVQ 2926_ DRVQG 2931_ YFASF 2936_ AKAYE 2941_ TVCKR 2946_ QDKEF 2951_ FGLRD 2956_ YYSLI 2961_ KMVFA 2966_ AAKAS 2971_ NRKPS 2976_ PQDIA 2981_ QAVLR 2986_ NFSGK 2991_ DDIQA 2996_ LDIFL 3001_ ANLPE 3006_ AKCSE 3011_ EVSPM 3016_ QLIKQ 3021_ NIFGP 3026_ SQKVP 3031_ GGEQE 3036_ DAESR 3041_ YLLVL 3046_ TKNYV 3051_ ALQIL 3056_ QQTFF 3061_ EGDQQ 3066_ PEIIF 3071_ GSGFP 3076_ KDQEY 3081_ TQLCR 3086_ NINRV 3091_ KICME 3096_ TGKMV 3101_ LLLNL 3106_ QNLYE 3111_ SLYDA 3116_ LNQYY 3121_ VHLGG 3126_ QKYVD 3131_ LGLGT 3136_ HRVKC 3141_ RVHPN 3146_ FRLIV 3151_ IEEKD 3156_ VVYKH 3161_ FPIPL 3166_ INRLE 3171_ KHYLD 3176_ INTVL 3181_ EKWQK 3186_ SIVEE 3191_ LCAWV 3196_ EKFIN 3201_ VKAHH 3206_ FQKRH 3211_ KYSPS 3216_ DVFIG 3221_ YHSDA 3226_ CASVV 3231_ LQVIE 3236_ RQGPR 3241_ ALTEE 3246_ LHQKV 3251_ SEEAK 3256_ SILLN 3261_ CATPD 3266_ AVVRL 3271_ SAYSL 3276_ GGFAA 3281_ EWLSQ 3286_ EYFHR 3291_ QRHNS 3296_ FADFL 3301_ QAHLH 3306_ TADLE 3311_ RHAIF 3316_ TEITT 3321_ FSRLL 3326_ TSHDC 3331_ EILES 3336_ EVTGR 3341_ APKPT 3346_ LLWLQ 3351_ QFDTE 3356_ YSFLK 3361_ EVRNC 3366_ LTNTA 3371_ KCKIL 3376_ IFQTD 3381_ FEDGI 3386_ RSAQL 3391_ IASAK 3396_ YSVIN 3401_ EINKI 3406_ RENED 3411_ RIFVY 3416_ FITKL 3421_ SRVGR 3426_ GTAYV 3431_ GFHGG 3436_ LWQSV 3441_ HIDDL 3446_ RRSTL 3451_ MVSDV 3456_ TRLQH 3461_ VTISQ 3466_ LFAPG 3471_ DLPEL 3476_ GLEHR 3481_ AEDGH 3486_ EEAME 3491_ TEAST 3496_ SGEVA 3501_ EVAEE 3506_ AMETE 3511_ SSEKV 3516_ GKETS 3521_ ELGGS 3526_ DVSIL 3531_ DTTRL 3536_ LRSCV 3541_ QSAVG 3546_ MLRDQ 3551_ NESCT 3556_ RNMRR 3561_ VVLLL 3566_ GLLNE 3571_ DDACH 3576_ ASFLR 3581_ VSKMR 3586_ LSVFL 3591_ KKQEE 3596_ SQFHP 3601_ LEWLA 3606_ REACN 3611_ QDALQ 3616_ EAGTF 3621_ RHTLW 3626_ KRVQG 3631_ AVTPL 3636_ LASMI 3641_ SFIDR 3646_ DGNLE 3651_ LLTRP 3656_ DTPPW 3661_ ARDLW 3666_ MFIFS 3671_ DTMLL 3676_ NIPLV 3681_ MNNER 3686_ HKGEM 3691_ AYIVV 3696_ QNHMN 3701_ LSENA 3706_ SNNVP 3711_ FSWKI 3716_ KDYLE 3721_ ELWVQ 3726_ AQYIT 3731_ DAEGL 3736_ PKKFV 3741_ DIFQQ 3746_ TPLGR 3751_ FLAQL 3756_ HGEPQ 3761_ QELLQ 3766_ CYLKD 3771_ FILLT 3776_ MRVST 3781_ EEELK 3786_ FLQMA 3791_ LWSCT 3796_ RKLKA 3801_ ASEAP 3806_ EEEVS 3811_ LPWVH 3816_ LAYQR 3821_ FRSRL 3826_ QNFSR 3831_ ILTIY 3836_ PQVLH 3841_ SLMEA 3846_ RWNHE 3851_ LAGCE 3856_ MTLDA 3861_ FAAMA 3866_ CTEML 3871_ TRNTL 3876_ KPSPQ 3881_ AWLQL 3886_ VKNLS 3891_ MPLEL 3896_ ICSDE 3901_ HMQGS 3906_ GSLAQ 3911_ AVIRE 3916_ VRAQW 3921_ SRIFS 3926_ TALFV 3931_ EHVLL 3936_ GTESR 3941_ VPELQ 3946_ GLVTE 3951_ HVFLL 3956_ DKCLR 3961_ ENSDV 3966_ KTHGP 3971_ FEAVM 3976_ RTLCE 3981_ CKETA 3986_ SKTLS 3991_ RFGIQ 3996_ PCSIC 4001_ LGDAK 4006_ DPVCL 4011_ PCDHV 4016_ HCLRC 4021_ LRAWF 4026_ ASEQM 4031_ ICPYC 4036_ LTALP 4041_ DEFSP 4046_ AVSQA 4051_ HREAI 4056_ EKHAR 4061_ FRQMC 4066_ NSFFV 4071_ DLVST 4076_ ICFKD 4081_ NAPPE 4086_ KEVIE 4091_ SLLSL 4096_ LFVQK 4101_ GRLRD 4106_ AAQRH 4111_ CEHTK 4116_ SLSPF 4121_ NDVVD 4126_ KTPVI 4131_ RSVIL 4136_ KLLLK 4141_ YSFHD 4146_ VKDYI 4151_ QEYLT 4156_ LLKKK 4161_ AFITE 4166_ DKTEL 4171_ YMLFI 4176_ NCLED 4181_ SILEK 4186_ TSAYS 4191_ RNDEL 4196_ NHLEE 4201_ EGRFL 4206_ KAYSP 4211_ ASRGR 4216_ EPANE 4221_ ASVEY 4226_ LQEVA 4231_ RIRLC 4236_ LDRAA 4241_ DFLSE 4246_ PEGGP 4251_ EMAKE 4256_ KQCYL 4261_ QQVKQ 4266_ FCIRV 4271_ ENDWH 4276_ RVYLV 4281_ RKLSS 4286_ QRGME 4291_ FVQGL 4296_ SKPGR 4301_ PHQWV 4306_ FPKDV 4311_ VKQQG 4316_ LRQDH 4321_ PGQMD 4326_ RYLVY 4331_ GDEYK 4336_ ALRDA 4341_ VAKAV 4346_ LECKP 4351_ LGIKT 4356_ ALKAC 4361_ KTPQS 4366_ QQSAY 4371_ FLLTL 4376_ FREVA 4381_ ILYRS 4386_ HNASL 4391_ HPTPE 4396_ QCEAV 4401_ SKFIG 4406_ ECKIL 4411_ SPPDI 4416_ SRFAT 4421_ SLVDN 4426_ SVPLL 4431_ RAGPS 4436_ DSNLD 4441_ GTVTE 4446_ MAIHA 4451_ AAVLL 4456_ CGQNE 4461_ LLEPL 4466_ KNLAF 4471_ SPATM 4476_ AHAFL 4481_ PTMPE 4486_ DLLAQ 4491_ ARRWK 4496_ GLERV 4501_ HWYTC 4506_ PNGHP 4511_ CSVGE 4516_ CGRPM 4521_ EQSIC 4526_ IDCHA 4531_ PIGGI 4536_ DHKPR 4541_ DGFHL 4546_ VKDKA 4551_ DRTQT 4556_ GHVLG 4561_ NPQRR 4566_ DVVTC 4571_ DRGLP 4576_ PVVFL 4581_ LIRLL 4586_ THLAL 4591_ LLGAS 4596_ QSSQA 4601_ LINII 4606_ KPPVR 4611_ DPKGF 4616_ LQQHI 4621_ LKDLE 4626_ QLAKM 4631_ LGHSA 4636_ DETIG 4641_ VVHLV 4646_ LRRLL 4651_ QEQHQ 4656_ LSSRR 4661_ LLNFD 4666_ TELST 4671_ KEMRN 4676_ NWEKE 4681_ IAAVI 4686_ SPELE 4691_ HLDKT 4696_ LPTMN 4701_ NLISQ 4706_ DKRIS 4711_ SNPVA 4716_ KIIYG 4721_ DPVTF 4726_ LPHLP 4731_ RKSVV 4736_ HCSKI 4741_ WSCRK 4746_ RITVE 4751_ YLQHI 4756_ VEQKN 4761_ GKERV 4766_ PILWH 4771_ FLQKE 4776_ AELRL 4781_ VKFLP 4786_ EILAL 4791_ QRDLV 4796_ KQFQN 4801_ VQQVE 4806_ YSSIR 4811_ GFLSK 4816_ HSSDG 4821_ LRQLL 4826_ HNRIT 4831_ VFLST 4836_ WNKLR 4841_ RSLET 4846_ NGEIN 4851_ LPKDY 4856_ CSTDL 4861_ DLDTE 4866_ FEILL 4871_ PRRRG 4876_ LGLCA 4881_ TALVS 4886_ YLIRL 4891_ HNEIV 4896_ YAVEK 4901_ LSKEN 4906_ NSYSV 4911_ DAAEV 4916_ TELHV 4921_ ISYEV 4926_ ERDLT 4931_ PLILS 4936_ NCQYQ 4941_ VEEGR 4946_ ETVQE 4951_ FDLEK 4956_ IQRQI 4961_ VSRFL 4966_ QGKPR 4971_ LSLKG 4976_ IPTLV 4981_ YRHDW 4986_ NYEHL 4991_ FMDIK 4996_ NKMAQ 5001_ DSLPS 5006_ SVISA 5011_ ISGQL 5016_ QSYSD 5021_ ACEVL 5026_ SVVEV 5031_ TLGFL 5036_ STAGG 5041_ DPNMQ 5046_ LNVYT 5051_ QDILQ 5056_ MGDQT 5061_ IHVLK 5066_ ALNRC 5071_ QLKHT 5076_ IALWQ 5081_ FLSAH 5086_ KSEQL 5091_ LRLHK 5096_ EPFGE 5101_ ISSRY 5106_ KADLS 5111_ PENAK 5116_ LLSTF 5121_ LNQTG 5126_ LDAFL 5131_ LELHE 5136_ MIILK 5141_ LKNPQ 5146_ TQTEE 5151_ RFRPQ 5156_ WSLRD 5161_ TLVSY 5166_ MQTKE 5171_ SEILP 5176_ EMASQ 5181_ FPEEI 5186_ LLASC 5191_ VSVWK 5196_ TAAVL 5201_KWNRE
1: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115)