AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin)
1_MGNCC 6_ WTQCF 11_ GLLRK 16_ EAGRL 21_ QRVGG 26_ GGGSK 31_ YFRTC 36_ SRGEH 41_ LTIEF 46_ ENLVE 51_ SDEGE 56_ SPGSS 61_ HRPLT 66_ EEEIV 71_ DLRER 76_ HYDSI 81_ AEKQK 86_ DLDKK 91_ IQKEL 96_ ALQEE 101_ KLRLE 106_ EEALY 111_ AAQRE 116_ AARAA 121_ KQRKL 126_ LEQER 131_ QRIVQ 136_ QYHPS 141_ NNGEY 146_ QSSGP 151_ EDDFE 156_ SCLRN 161_ MKSQY 166_ EVFRS 171_ SRLSS 176_ DATVL 181_ TPNTE 186_ SSCDL 191_ MTKTK 196_ STSGN 201_ DDSTS 206_ LDLEW 211_ EDEEG 216_ MNRML 221_ PMRER 226_ SKTEE 231_ DILRA 236_ ALKYS 241_ NKKTG 246_ SNPTS 251_ ASDDS 256_ NGLEW 261_ ENDFV 266_ SAEMD 271_ DNGNS 276_ EYSGF 281_ VNPVL 286_ ELSDS 291_ GIRHS 296_DTDQQ
1: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex