Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
1_MKSSG 6_ PVERL 11_ LRALG 16_ RRDSS 21_ RAASR 26_ PRKAE 31_ PHSFR 36_ EKVFR 41_ KKPPV 46_ CAVCK 51_ VTIDG 56_ TGVSC 61_ RVCKV 66_ ATHRK 71_ CEAKV 76_ TSACQ 81_ ALPPV 86_ ELRRN 91_ TAPVR 96_ RIEHL 101_ GSTKS 106_ LNHSK 111_ QRSTL 116_ PRSFS 121_ LDPLM 126_ ERRWD 131_ LDLTY 136_ VTERI 141_ LAAAF 146_ PARPD 151_ EQRHR 156_ GHLRE 161_ LAHVL 166_ QSKHR 171_ DKYLL 176_ FNLSE 181_ KRHDL 186_ TRLNP 191_ KVQDF 196_ GWPEL 201_ HAPPL 206_ DKLCS 211_ ICKAM 216_ ETWLS 221_ ADPQH 226_ VVVLY 231_ CKGNK 236_ GKLGV 241_ IVSAY 246_ MHYSK 251_ ISAGA 256_ DQALA 261_ TLTMR 266_ KFCED 271_ KVATE 276_ LQPSQ 281_ RRYIS 286_ YFSGL 291_ LSGSI 296_ RMNSS 301_ PLFLH 306_ YVLIP 311_ MLPAF 316_ EPGTG 321_ FQPFL 326_ KIYQS 331_ MQLVY 336_ TSGVY 341_ HIAGP 346_ GPQQL 351_ CISLE 356_ PALLL 361_ KGDVM 366_ VTCYH 371_ KGGRG 376_ TDRTL 381_ VFRVQ 386_ FHTCT 391_ IHGPQ 396_ LTFPK 401_ DQLDE 406_ AWTDE 411_ RFPFQ 416_ ASVEF 421_ VFSSS 426_ PEKIK 431_ GSTPR 436_ NDPSV 441_ SVDYN 446_ TTEPA 451_ VRWDS 456_ YENFN 461_ QHHED 466_ SVDGS 471_ LTHTR 476_ GPLDG 481_ SPYAQ 486_ VQRPP 491_ RQTPP 496_ APSPE 501_ PPPPP 506_ MLSVS 511_ SDSGH 516_ SSTLT 521_ TEPAA 526_ ESPGR 531_ PPPTA 536_ AERQE 541_ LDRLL 546_ GGCGV 551_ ASGGR 556_ GAGRE 561_ TAILD 566_ DEEQP 571_ TVGGG 576_ PHLGV 581_ YPGHR 586_ PGLSR 591_ HCSCR 596_ QGYRE 601_ PCGVP 606_ NGGYY 611_ RPEGT 616_ LERRR 621_ LAYGG 626_ YEGSP 631_ QGYAE 636_ ASMEK 641_ RRLCR 646_ SLSEG 651_ LYPYP 656_ PEMGK 661_ PATGD 666_ FGYRA 671_ PGYRE 676_ VVILE 681_ DPGLP 686_ ALYPC 691_ PACEE 696_ KLALP 701_ TAALY 706_ GLRLE 711_ REAGE 716_ GWASE 721_ AGKPL 726_ LHPVR 731_ PGHPL 736_ PLLLP 741_ ACGHH 746_ HAPMP 751_ DYSCL 756_ KPPKA 761_ GEEGH 766_ EGCSY 771_ TMCPE 776_ GRYGH 781_ PGYPA 786_ LVTYS 791_ YGGAV 796_ PSYCP 801_ AYGRV 806_ PHSCG 811_ SPGEG 816_ RGYPS 821_ PGAHS 826_ PRAGS 831_ ISPGS 836_ PPYPQ 841_ SRKLS 846_ YEIPT 851_ EEGGD 856_ RYPLP 861_ GHLAS 866_ AGPLA 871_ SAESL 876_ EPVSW 881_ REGPS 886_ GHSTL 891_ PRSPR 896_ DAPCS 901_ ASSEL 906_ SGPST 911_ PLHTS 916_ SPVQG 921_ KESTR 926_ RQDTR 931_ SPTSA 936_ PTQRL 941_ SPGEA 946_ LPPVS 951_ QAGTG 956_ KAPEL 961_ PSGSG 966_ PEPLA 971_ PSPVS 976_ PTFPP 981_ SSPSD 986_ WPQER 991_ SPGGH 996_ SDGAS 1001_ PRSPV 1006_ PTTLP 1011_ GLRHA 1016_ PWQGP 1021_ RGPPD 1026_ SPDGS 1031_ PLTPV 1036_ PSQMP 1041_ WLVAS 1046_ PEPPQ 1051_ SSPTP 1056_ AFPLA 1061_ ASYDT 1066_ NGLSQ 1071_ PPLPE 1076_ KRHLP 1081_ GPGQQ 1086_ PGPWG 1091_ PEQAS 1096_ SPARG 1101_ ISHHV 1106_ TFAPL 1111_ LSDNV 1116_ PQTPE 1121_ PPTQE 1126_ SQSNV 1131_ KFVQD 1136_ TSKFW 1141_ YKPHL 1146_ SRDQA 1151_ IALLK 1156_ DKDPG 1161_ AFLIR 1166_ DSHSF 1171_ QGAYG 1176_ LALKV 1181_ ATPPP 1186_ SAQPW 1191_ KGDPV 1196_ EQLVR 1201_ HFLIE 1206_ TGPKG 1211_ VKIKG 1216_ CPSEP 1221_ YFGSL 1226_ SALVS 1231_ QHSIS 1236_ PISLP 1241_ CCLRI 1246_ PSKDP 1251_ LEETP 1256_ EAPVP 1261_ TNMST 1266_ AADLL 1271_ RQGAA 1276_ CSVLY 1281_ LTSVE 1286_ TESLT 1291_ GPQAV 1296_ ARASS 1301_ AALSC 1306_ SPRPT 1311_ PAVVH 1316_ FKVSA 1321_ QGITL 1326_ TDNQR 1331_ KLFFR 1336_ RHYPV 1341_ NSITF 1346_ SSTDP 1351_ QDRRW 1356_ TNPDG 1361_ TTSKI 1366_ FGFVA 1371_ KKPGS 1376_ PWENV 1381_ CHLFA 1386_ ELDPD 1391_ QPAGA 1396_ IVTFI 1401_TKVLL
1: Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572)