KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)
1_MAQVL 6_ HVPAP 11_ FPGTP 16_ GPASP 21_ PAFPA 26_ KDPDP 31_ PYSVE 36_ TPYGY 41_ RLDLD 46_ FLKYV 51_ DDIEK 56_ GHTLR 61_ RVAVQ 66_ RRPRL 71_ SSLPR 76_ GPGSW 81_ WTSTE 86_ SLCSN 91_ ASGDS 96_ RHSAY 101_ SYCGR 106_ GFYPQ 111_ YGALE 116_ TRGGF 121_ NPRVE 126_ RTLLD 131_ ARRRL 136_ EDQAA 141_ TPTGL 146_ GSLTP 151_ SAAGS 156_ TASLV 161_ GVGLP 166_ PPTPR 171_ SSGLS 176_ TPVPP 181_ SAGHL 186_ AHVRE 191_ QMAGA 196_ LRKLR 201_ QLEEQ 206_ VKLIP 211_ VLQVK 216_ LSVLQ 221_ EEKRQ 226_ LTVQL 231_ KSQKF 236_ LGHPT 241_ AGRGR 246_ SELCL 251_ DLPDP 256_ PEDPV 261_ ALETR 266_ SVGTW 271_ VRERD 276_ LGMPD 281_ GEAAL 286_ AAKVA 291_ VLETQ 296_ LKKAL 301_ QELQA 306_ AQARQ 311_ ADPQP 316_ QAWPP 321_ PDSPV 326_ RVDTV 331_ RVVEG 336_ PREVE 341_ VVAST 346_ AAGAP 351_ AQRAQ 356_ SLEPY 361_ GTGLR 366_ ALAMP 371_ GRPES 376_ PPVFR 381_ SQEVV 386_ ETMCP 391_ VPAAA 396_ TSNVH 401_ MVKKI 406_ SITER 411_ SCDGA 416_ AGLPE 421_ VPAES 426_ SSSPP 431_ GSEVA 436_ SLTQP 441_ EKSTG 446_ RVPTQ 451_ EPTHR 456_ EPTRQ 461_ AASQE 466_ SEEAG 471_ GTGGP 476_ PAGVR 481_ SIMKR 486_ KEEVA 491_ DPTAH 496_ RRSLQ 501_ FVGVN 506_ GGYES 511_ SSEDS 516_ STAEN 521_ ISDND 526_ STENE 531_ APEPR 536_ ERVPS 541_ VAEAP 546_ QLRPA 551_ GTAAA 556_ KTSRQ 561_ ECQLS 566_ RESQH 571_ IPTAE 576_ GASGS 581_ NTEEE 586_ IRMEL 591_ SPDLI 596_ SACLA 601_ LEKYL 606_ DNPNA 611_ LTERE 616_ LKVAY 621_ TTVLQ 626_ EWLRL 631_ ACRSD 636_ AHPEL 641_ VRRHL 646_ VTFRA 651_ MSARL 656_ LDYVV 661_ NIADS 666_ NGNTA 671_ LHYSV 676_ SHANF 681_ PVVQQ 686_ LLDSG 691_ VCKVD 696_ KQNRA 701_ GYSPI 706_ MLTAL 711_ ATLKT 716_ QDDIE 721_ TVLQL 726_ FRLGN 731_ INAKA 736_ SQAGQ 741_ TALML 746_ AVSHG 751_ RVDVV 756_ KALLA 761_ CEADV 766_ NVQDD 771_ DGSTA 776_ LMCAC 781_ EHGHK 786_ EIAGL 791_ LLAVP 796_ SCDIS 801_ LTDRD 806_ GSTAL 811_ MVALD 816_ AGQSE 821_ IASML 826_ YSRMN 831_ IKCSF 836_ APMSD 841_ DESPT 846_SSSAE
1: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity)