WASH complex subunit 2A
1_MMNRT 6_ TPDQE 11_ LAPAS 16_ EPVWE 21_ RPWSV 26_ EEIRR 31_ SSQSW 36_ SLAAD 41_ AGLLQ 46_ FLQEF 51_ SQQTI 56_ SRTHE 61_ IKKQV 66_ DGLIR 71_ ETKAT 76_ DCRLH 81_ NVFND 86_ FLMLS 91_ NTQFI 96_ ENRVY 101_ DEEVE 106_ EPVLK 111_ AEAEK 116_ TEQEK 121_ TREQK 126_ EVDLI 131_ PKVQE 136_ AVNYG 141_ LQVLD 146_ SAFEQ 151_ LDIKA 156_ GNSDS 161_ EEDDA 166_ NGRVE 171_ LILEP 176_ KDLYI 181_ DRPLP 186_ YLIGS 191_ KLFME 196_ QEDVG 201_ LGELS 206_ SEEGS 211_ VGSDR 216_ GSIVD 221_ TEEEK 226_ EEEES 231_ DEDFA 236_ HHSDN 241_ EQNRH 246_ TTQMS 251_ DEEED 256_ DDGCD 261_ LFADS 266_ EKEEE 271_ DIEDI 276_ EENTR 281_ PKRSR 286_ PTSFA 291_ DELAA 296_ RIKGD 301_ AVGRV 306_ DEEPT 311_ TLPSG 316_ EAKPR 321_ KTLKE 326_ KKERR 331_ TPSDD 336_ EEDNL 341_ FAPPK 346_ LTDED 351_ FSPFG 356_ SGGGL 361_ FSGGK 366_ GLFDD 371_ EDEES 376_ DLFTE 381_ APQDR 386_ QAGAS 391_ VKEES 396_ SSSKP 401_ GKKIP 406_ AGAVS 411_ VFLGD 416_ TDVFG 421_ AASVP 426_ SMKEP 431_ QKPEQ 436_ PTPRK 441_ SPYGP 446_ PPTGL 451_ FDDDD 456_ GDDDD 461_ DFFSA 466_ PHSKP 471_ SKTGK 476_ VQSTA 481_ DIFGD 486_ EEGDL 491_ FKEKA 496_ VASPE 501_ ATVSQ 506_ TDENK 511_ ARAEK 516_ KVTLS 521_ SSKNL 526_ KPSSE 531_ TKTQK 536_ GLFSD 541_ EEDSE 546_ DLFSS 551_ QSASK 556_ LKGAS 561_ LLPGK 566_ LPTLV 571_ SLFDD 576_ EDEED 581_ NLFGG 586_ TAAKK 591_ QTLCL 596_ QAQRE 601_ EKAKA 606_ SELSK 611_ KKASA 616_ LLFSS 621_ DEEDQ 626_ WNIPA 631_ SQTHL 636_ ASDSR 641_ SKGEP 646_ RDSGT 651_ LQSQE 656_ AKAVK 661_ KTSLF 666_ EEDEE 671_ DDLFA 676_ IAKDS 681_ QKKTQ 686_ RVSLL 691_ FEDDV 696_ DSGGS 701_ LFGSP 706_ PTSVP 711_ PATKK 716_ KETVS 721_ EAPPL 726_ LFSDE 731_ EEKEA 736_ QLGVK 741_ SVDKK 746_ VESAK 751_ ESLKF 756_ GRTDV 761_ AESEK 766_ EGLLT 771_ RSAQE 776_ TVKHS 781_ DLFSS 786_ SSPWD 791_ KGTKP 796_ RTKTV 801_ LSLFD 806_ EEEDK 811_ MEDQN 816_ IIQAP 821_ QKEVG 826_ KGRDP 831_ DAHPK 836_ STGVF 841_ QDEEL 846_ LFSHK 851_ LQKDN 856_ DPDVD 861_ LFAGT 866_ KKTKL 871_ LEPSV 876_ GSLFG 881_ DDEDD 886_ DLFSS 891_ AKSQP 896_ LVQEK 901_ KRVVK 906_ KDHSV 911_ DSFKN 916_ QKHPE 921_ SIQGS 926_ KEKGI 931_ WKPET 936_ PQDSS 941_ GLAPF 946_ KTKEP 951_ STRIG 956_ KIQAN 961_ LAINP 966_ AALLP 971_ TAASQ 976_ ISEVK 981_ PVLPE 986_ LAFPS 991_ SEHRR 996_ SHGLE 1001_ SVPVL 1006_ PGSGE 1011_ AGVSF 1016_ DLPAQ 1021_ ADTLH 1026_ SANKS 1031_ RVKMR 1036_ GKRRP 1041_ QTRAA 1046_ RRLAA 1051_ QESSE 1056_ TEDMS 1061_ VPRGP 1066_ IAQWA 1071_ DGAIS 1076_ PNGHR 1081_ PQLRA 1086_ ASGED 1091_ STEEA 1096_ LAAAA 1101_ APWEG 1106_ GPVPG 1111_ VDRSP 1116_ FAKSL 1121_ GHSRG 1126_ EADLF 1131_ DSGDI 1136_ FSTGT 1141_ GSQSV 1146_ ERTKP 1151_ KAKIA 1156_ ENPAN 1161_ PPVGG 1166_ KAKSP 1171_ MFPAL 1176_ GEASS 1181_ DDDLF 1186_ QSAKP 1191_ KPAKK 1196_ TNPFP 1201_ LLEDE 1206_ DDLFT 1211_ DQKVK 1216_ KNETK 1221_ SNSQQ 1226_ DVILT 1231_ TQDIF 1236_ EDDIF 1241_ ATEAI 1246_ KPSQK 1251_ TREKE 1256_ KTLES 1261_ NLFDD 1266_ NIDIF 1271_ ADLTV 1276_ KPKEK 1281_ SKKKV 1286_ EAKSI 1291_ FDDDM 1296_ DDIFS 1301_ SGIQA 1306_ KTTKP 1311_ KSRSA 1316_ QAAPE 1321_ PRFEH 1326_ KVSNI 1331_ FDDPL 1336_NAFGG
1: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L