Meteorin-like protein (Subfatin)
1_MRGAA 6_ RAAWG 11_ RAGQP 16_ WPRPP 21_ APGPP 26_ PPPLP 31_ LLLLL 36_ LAGLL 41_ GGAGA 46_ QYSSD 51_ RCSWK 56_ GSGLT 61_ HEAHR 66_ KEVEQ 71_ VYLRC 76_ AAGAV 81_ EWMYP 86_ TGALI 91_ VNLRP 96_ NTFSP 101_ ARHLT 106_ VCIRS 111_ FTDSS 116_ GANIY 121_ LEKTG 126_ ELRLL 131_ VPDGD 136_ GRPGR 141_ VQCFG 146_ LEQGG 151_ LFVEA 156_ TPQQD 161_ IGRRT 166_ TGFQY 171_ ELVRR 176_ HRASD 181_ LHELS 186_ APCRP 191_ CSDTE 196_ VLLAV 201_ CTSDF 206_ AVRGS 211_ IQQVT 216_ HEPER 221_ QDSAI 226_ HLRVS 231_ RLYRQ 236_ KSRVF 241_ EPVPE 246_ GDGHW 251_ QGRVR 256_ TLLEC 261_ GVRPG 266_ HGDFL 271_ FTGHM 276_ HFGEA 281_ RLGCA 286_ PRFKD 291_ FQRMY 296_ RDAQE 301_ RGLNP 306_CEVGT
1: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity)