Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
1_MPEEM 6_ DKPLI 11_ SLHLV 16_ DSDSS 21_ LAKVP 26_ DEAPK 31_ VGILG 36_ SGDFA 41_ RSLAT 46_ RLVGS 51_ GFKVV 56_ VGSRN 61_ PKRTA 66_ RLFPS 71_ AAQVT 76_ FQEEA 81_ VSSPE 86_ VIFVA 91_ VFREH 96_ YSSLC 101_ SLSDQ 106_ LAGKI 111_ LVDVS 116_ NPTEQ 121_ EHLQH 126_ RESNA 131_ EYLAS 136_ LFPTC 141_ TVVKA 146_ FNVIS 151_ AWTLQ 156_ AGPRD 161_ GNRQV 166_ PICGD 171_ QPEAK 176_ RAVSE 181_ MALAM 186_ GFMPV 191_ DMGSL 196_ ASAWE 201_ VEAMP 206_ LRLLP 211_ AWKVP 216_ TLLAL 221_ GLFVC 226_ FYAYN 231_ FVRDV 236_ LQPYV 241_ QESQN 246_ KFFKL 251_ PVSVV 256_ NTTLP 261_ CVAYV 266_ LLSLV 271_ YLPGV 276_ LAAAL 281_ QLRRG 286_ TKYQR 291_ FPDWL 296_ DHWLQ 301_ HRKQI 306_ GLLSF 311_ FCAAL 316_ HALYS 321_ FCLPL 326_ RRAHR 331_ YDLVN 336_ LAVKQ 341_ VLANK 346_ SHLWV 351_ EEEVW 356_ RMEIY 361_ LSLGV 366_ LALGT 371_ LSLLA 376_ VTSLP 381_ SIANS 386_ LNWRE 391_ FSFVQ 396_ SSLGF 401_ VALVL 406_ STLHT 411_ LTYGW 416_ TRAFE 421_ ESRYK 426_ FYLPP 431_ TFTLT 436_ LLVPC 441_ VVILA 446_ KALFL 451_ LPCIS 456_ RRLAR 461_ IRRGW 466_ EREST 471_ IKFTL 476_ PTDHA 481_LAEKT
1: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434)