Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
1_MEGAM 6_ AVRVT 11_ AAHTA 16_ EAQAE 21_ AGREA 26_ GEGAV 31_ AAVAA 36_ ALAPS 41_ GFLGL 46_ PAPFS 51_ EEDED 56_ DVHRC 61_ GRCQA 66_ EFTAL 71_ EDFVQ 76_ HKIQK 81_ ACQRA 86_ PPEAL 91_ PATPA 96_ TTALL 101_ GQEVV 106_ PAAPG 111_ PEEPI 116_ TVAHI 121_ VVEAA 126_ SLAAD 131_ ISHAS 136_ DLVGG 141_ GHIKE 146_ VIVAA 151_ EAELG 156_ DGEMA 161_ EAPGS 166_ PRQQG 171_ LGLAG 176_ EGEQA 181_ QVKLL 186_ VNKDG 191_ RYVCA 196_ LCHKT 201_ FKTGS 206_ ILKAH 211_ MVTHS 216_ SRKDH 221_ ECKLC 226_ GASFR 231_ TKGSL 236_ IRHHR 241_ RHTDE 246_ RPYKC 251_ SKCGK 256_ SFRES 261_ GALTR 266_ HLKSL 271_ TPCTE 276_ KIRFS 281_ VSKDV 286_ VVSKE 291_ DARAG 296_ SGAGA 301_ AGLGT 306_ ATSSV 311_ TGEPI 316_ ETSPV 321_ IHLVT 326_ DAKGT 331_ VIHEV 336_ HVQMQ 341_ ELSLG 346_ MKALA 351_ PEPPV 356_ SQELP 361_ CSSEG 366_ SRENL 371_ LHQAM 376_ QNSGI 381_ VLERA 386_ AGEEG 391_ ALEPA 396_ PAAGS 401_ SPQPL 406_ AVAAP 411_ QLPVL 416_ EVQPL 421_ ETQVA 426_ SEASA 431_ VPRTH 436_ PCPQC 441_ SETFP 446_ TAATL 451_ EAHKR 456_ GHTGP 461_ RPFAC 466_ AQCGK 471_ AFPKA 476_ YLLKK 481_ HQEVH 486_ VRERR 491_ FRCGD 496_ CGKLY 501_ KTIAH 506_ VRGHR 511_ RVHSD 516_ ERPYP 521_ CPKCG 526_ KRYKT 531_ KNAQQ 536_ VHFRT 541_ HLEEK 546_ PHVCQ 551_ FCSRG 556_ FREKG 561_ SLVRH 566_ VRHHT 571_ GEKPF 576_ KCYKC 581_ GRGFA 586_ EHGTL 591_ NRHLR 596_ TKGGC 601_ LLEVE 606_ ELLVS 611_ EDSPA 616_ AATTV 621_ LTEDP 626_ HTVLV 631_ EFSSV 636_ VADTQ 641_ EYIIE 646_ ATADD 651_ AETSE 656_ ATEII 661_ EGTQT 666_ EVDSH 671_ IMKVV 676_ QQIVH 681_ QASAG 686_ HQIIV 691_ QNVTM 696_ DEETA 701_ LGPEA 706_ AAADT 711_ ITIAT 716_ PESLT 721_ EQVAM 726_ TLASA 731_ ISEGT 736_ VLAAR 741_ AGTSG 746_ TEQAT 751_ VTMVS 756_ SEDIE 761_ ILEHA 766_ GELVI 771_ ASPEG 776_QLEVQ
1: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription
2: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes