Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE)
1_MVSRM 6_ GWGGR 11_ RRRLG 16_ RWGDL 21_ GPGSV 26_ PLLPM 31_ PLPPP 36_ PPPSC 41_ RGPGG 46_ GRISI 51_ FSLSP 56_ APHTR 61_ SSPSS 66_ FSPPT 71_ AGPPC 76_ SVLQG 81_ TGASQ 86_ SCHSA 91_ LPIPA 96_ TPPTQ 101_ AQPAM 106_ TPASA 111_ SPSWG 116_ SHSTP 121_ PLAPA 126_ TPTPS 131_ QQCPQ 136_ DSPGL 141_ RVGPL 146_ IPEQD 151_ YERLE 156_ DCDPE 161_ GSQDS 166_ PIHGE 171_ EQQPL 176_ LHVPE 181_ GLRGS 186_ WHHIQ 191_ NLDSF 196_ FTKIY 201_ SYHQR 206_ NGFAC 211_ ILLED 216_ VFQLG 221_ QFIFI 226_ VTFTT 231_ FLLRC 236_ VDYNV 241_ LFANQ 246_ PSNHT 251_ RPGPF 256_ HSKVT 261_ LSDAI 266_ LPSAQ 271_ CAERI 276_ RSSPL 281_ LVLLL 286_ VLAAG 291_ FWLVQ 296_ LLRSV 301_ CNLFS 306_ YWDIQ 311_ VFYRE 316_ ALHIP 321_ PEELS 326_ SVPWA 331_ EVQSR 336_ LLALQ 341_ RSGGL 346_ CVQPR 351_ PLTEL 356_ DIHHR 361_ ILRYT 366_ NYQVA 371_ LANKG 376_ LLPAR 381_ CPLPW 386_ GGSAA 391_ FLSRG 396_ LALNV 401_ DLLLF 406_ RGPFS 411_ LFRGG 416_ WELPH 421_ AYKRS 426_ DQRGA 431_ LAARW 436_ GRTVL 441_ LLAAL 446_ NLALS 451_ PLVLA 456_ WQVLH 461_ VFYSH 466_ VELLR 471_ REPGA 476_ LGARG 481_ WSRLA 486_ RLQLR 491_ HFNEL 496_ PHELR 501_ ARLAR 506_ AYRPA 511_ AAFLR 516_ TAAPP 521_ APLRT 526_ LLARQ 531_ LVFFA 536_ GALFA 541_ ALLVL 546_ TVYDE 551_ DVLAV 556_ EHVLT 561_ AMTAL 566_ GVTAT 571_ VARSF 576_ IPEEQ 581_ CQGRA 586_ PQLLL 591_ QTALA 596_ HMHYL 601_ PEEPG 606_ PGGRD 611_ RAYRQ 616_ MAQLL 621_ QYRAV 626_ SLLEE 631_ LLSPL 636_ LTPLF 641_ LLFWF 646_ RPRAL 651_ EIIDF 656_ FHHFT 661_ VDVAG 666_ VGDIC 671_ SFALM 676_ DVKRH 681_ GHPQW 686_ LSAGQ 691_ TEASL 696_ SQRAE 701_ DGKTE 706_ LSLMR 711_ FSLAH 716_ PLWRP 721_ PGHSS 726_ KFLGH 731_ LWGRV 736_ QQDAA 741_ AWGAT 746_ SARGP 751_ STPGV 756_ LSNCT 761_ SPLPE 766_ AFLAN 771_ LFVHP 776_ LLPPR 781_ DLSPT 786_ APCPA 791_ AATAS 796_ LLASI 801_ SRIAQ 806_ DPSSV 811_ SPGGT 816_ GGQKL 821_ AQLPE 826_ LASAE 831_ MSLHV 836_ IYLHQ 841_ LHQQQ 846_ QQQEP 851_ WGEAA 856_ ASILS 861_ RPCSS 866_ PSQPP 871_ SPDEE 876_ KPSWS 881_ SDGSS 886_ PASSP 891_ RQQWG 896_ TQKAR 901_ NLFPG 906_ GFQVT 911_ TDTQK 916_EPDRA
1: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity)