Autophagy-related protein 16-1 (APG16-like 1)
1_MSSGL 6_ RAADF 11_ PRWKR 16_ HISEQ 21_ LRRRD 26_ RLQRQ 31_ AFEEI 36_ ILQYN 41_ KLLEK 46_ SDLHS 51_ VLAQK 56_ LQAEK 61_ HDVPN 66_ RHEIS 71_ PGHDG 76_ TWNDN 81_ QLQEM 86_ AQLRI 91_ KHQEE 96_ LTELH 101_ KKRGE 106_ LAQLV 111_ IDLNN 116_ QMQRK 121_ DREMQ 126_ MNEAK 131_ IAECL 136_ QTISD 141_ LETEC 146_ LDLRT 151_ KLCDL 156_ ERANQ 161_ TLKDE 166_ YDALQ 171_ ITFTA 176_ LEGKL 181_ RKTTE 186_ ENQEL 191_ VTRWM 196_ AEKAQ 201_ EANRL 206_ NAENE 211_ KDSRR 216_ RQARL 221_ QKELA 226_ EAAKE 231_ PLPVE 236_ QDDDI 241_ EVIVD 246_ ETSDH 251_ TEETS 256_ PVRAI 261_ SRAAT 266_ KRLSQ 271_ PAGGL 276_ LDSIT 281_ NIFGR 286_ RSVSS 291_ FPVPQ 296_ DNVDT 301_ HPGSG 306_ KEVRV 311_ PATAL 316_ CVFDA 321_ HDGEV 326_ NAVQF 331_ SPGSR 336_ LLATG 341_ GMDRR 346_ VKLWE 351_ VFGEK 356_ CEFKG 361_ SLSGS 366_ NAGIT 371_ SIEFD 376_ SAGSY 381_ LLAAS 386_ NDFAS 391_ RIWTV 396_ DDYRL 401_ RHTLT 406_ GHSGK 411_ VLSAK 416_ FLLDN 421_ ARIVS 426_ GSHDR 431_ TLKLW 436_ DLRSK 441_ VCIKT 446_ VFAGS 451_ SCNDI 456_ VCTEQ 461_ CVMSG 466_ HFDKK 471_ IRFWD 476_ IRSES 481_ IVREM 486_ ELLGK 491_ ITALD 496_ LNPER 501_ TELLS 506_ CSRDD 511_ LLKVI 516_ DLRTN 521_ AIKQT 526_ FSAPG 531_ FKCGS 536_ DWTRV 541_ VFSPD 546_ GSYVA 551_ AGSAE 556_ GSLYI 561_ WSVLT 566_ GKVEK 571_ VLSKQ 576_ HSSSI 581_ NAVAW 586_ SPSGS 591_ HVVSV 596_ DKGCK 601_AVLWA
1: Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966)