Gene name: B3GNTL1

Uniprot entry:

Q67FW5

Protein names:

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (BGnT-like protein 1) (Beta1,3-N-acetylglucosaminyltransferase-like protein 1) (Beta3Gn-T-like protein 1) (Beta3GnTL1) (EC 2.4.1.-) (Beta-1,3-N-acetylglucosaminyltransferase 8) (BGnT-8) (Beta-1,3-Gn-T8) (Beta3Gn-T8)

Protein sequence:

1_MSGAG 6_ VGGAS 11_ EESQA 16_ MQAHV 21_ SIILP 26_ VHNAE 31_ PWLDE 36_ CLRSV 41_ LQQDF 46_ EGTME 51_ LSVFN 56_ DASKD 61_ KSGAI 66_ IEKWR 71_ VKLED 76_ SGVHV 81_ IIGGH 86_ DSPSP 91_ RGVGY 96_ AKNQA 101_ VAQSS 106_ GSYLC 111_ FLDSD 116_ DVMMP 121_ QRVRL 126_ QHEAA 131_ VQHPS 136_ SIIGC 141_ RVRRD 146_ PPNST 151_ ERYTR 156_ WINQL 161_ TPEQL 166_ LTQVF 171_ TSNGP 176_ TVIMP 181_ TWFCS 186_ RAWFS 191_ HVGPF 196_ NEGGQ 201_ GVPED 206_ LLFFY 211_ EHLRK 216_ GGGVI 221_ RVDQS 226_ LLLYR 231_ HHPQA 236_ ATHCV 241_ LETTI 246_ WTHRV 251_ RFLEE 256_ QALPR 261_ WAAFT 266_ IWNAG 271_ KQGRR 276_ LYRSL 281_ TAGSQ 286_ RKVVA 291_ FCDVD 296_ ENKIR 301_ KGFYC 306_ HEDSQ 311_ ERPKP 316_ RIPIL 321_ HFRAA 326_ RPPFV 331_ ICVKL 336_ DLTGG 341_ AFEDN 346_ LRSLH 351_ LQEGQ 356_DFLHF

Protein annotations

Protein functions:

1: Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation (PubMed:37992713)