Metalloreductase STEAP4 (EC 1.16.1.9) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)
1_MEKTC 6_ IDALP 11_ LTMNS 16_ SEKQE 21_ TVCIF 26_ GTGDF 31_ GRSLG 36_ LKMLQ 41_ CGYSV 46_ VFGSR 51_ NPQKT 56_ TLLPS 61_ GAEVL 66_ SYSEA 71_ AKKSG 76_ IIIIA 81_ IHREH 86_ YDFLT 91_ ELTEV 96_ LNGKI 101_ LVDIS 106_ NNLKI 111_ NQYPE 116_ SNAEY 121_ LAHLV 126_ PGAHV 131_ VKAFN 136_ TISAW 141_ ALQSG 146_ ALDAS 151_ RQVFV 156_ CGNDS 161_ KAKQR 166_ VMDIV 171_ RNLGL 176_ TPMDQ 181_ GSLMA 186_ AKEIE 191_ KYPLQ 196_ LFPMW 201_ RFPFY 206_ LSAVL 211_ CVFLF 216_ FYCVI 221_ RDVIY 226_ PYVYE 231_ KKDNT 236_ FRMAI 241_ SIPNR 246_ IFPIT 251_ ALTLL 256_ ALVYL 261_ PGVIA 266_ AILQL 271_ YRGTK 276_ YRRFP 281_ DWLDH 286_ WMLCR 291_ KQLGL 296_ VALGF 301_ AFLHV 306_ LYTLV 311_ IPIRY 316_ YVRWR 321_ LGNLT 326_ VTQAI 331_ LKKEN 336_ PFSTS 341_ SAWLS 346_ DSYVA 351_ LGILG 356_ FFLFV 361_ LLGIT 366_ SLPSV 371_ SNAVN 376_ WREFR 381_ FVQSK 386_ LGYLT 391_ LILCT 396_ AHTLV 401_ YGGKR 406_ FLSPS 411_ NLRWY 416_ LPAAY 421_ VLGLI 426_ IPCTV 431_ LVIKF 436_ VLIMP 441_ CVDNT 446_ LTRIR 451_QGWER
1: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18381574, PubMed:18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193)