Tensin-3 (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)
1_MEEGH 6_ GLDLT 11_ YITER 16_ IIAVS 21_ FPAGC 26_ SEESY 31_ LHNLQ 36_ EVTRM 41_ LKSKH 46_ GDNYL 51_ VLNLS 56_ EKRYD 61_ LTKLN 66_ PKIMD 71_ VGWPE 76_ LHAPP 81_ LDKMC 86_ TICKA 91_ QESWL 96_ NSNLQ 101_ HVVVI 106_ HCRGG 111_ KGRIG 116_ VVISS 121_ YMHFT 126_ NVSAS 131_ ADQAL 136_ DRFAM 141_ KKFYD 146_ DKVSA 151_ LMQPS 156_ QKRYV 161_ QFLSG 166_ LLSGS 171_ VKMNA 176_ SPLFL 181_ HFVIL 186_ HGTPN 191_ FDTGG 196_ VCRPF 201_ LKLYQ 206_ AMQPV 211_ YTSGI 216_ YNVGP 221_ ENPSR 226_ ICIVI 231_ EPAQL 236_ LKGDV 241_ MVKCY 246_ HKKYR 251_ SATRD 256_ VIFRL 261_ QFHTG 266_ AVQGY 271_ GLVFG 276_ KEDLD 281_ NASKD 286_ DRFPD 291_ YGKVE 296_ LVFSA 301_ TPEKI 306_ QGSEH 311_ LYNDH 316_ GVIVD 321_ YNTTD 326_ PLIRW 331_ DSYEN 336_ LSADG 341_ EVLHT 346_ QGPVD 351_ GSLYA 356_ KVRKK 361_ SSSDP 366_ GIPGG 371_ PQAIP 376_ ATNSP 381_ DHSDH 386_ TLSVS 391_ SDSGH 396_ STASA 401_ RTDKT 406_ EERLA 411_ PGTRR 416_ GLSAQ 421_ EKAEL 426_ DQLLS 431_ GFGLE 436_ DPGSS 441_ LKEMT 446_ DARSK 451_ YSGTR 456_ HVVPA 461_ QVHVN 466_ GDAAL 471_ KDRET 476_ DILDD 481_ EMPHH 486_ DLHSV 491_ DSLGT 496_ LSSSE 501_ GPQSA 506_ HLGPF 511_ TCHKS 516_ SQNSL 521_ LSDGF 526_ GSNVG 531_ EDPQG 536_ TLVPD 541_ LGLGM 546_ DGPYE 551_ RERTF 556_ GSREP 561_ KQPQP 566_ LLRKP 571_ SVSAQ 576_ MQAYG 581_ QSSYS 586_ TQTWV 591_ RQQQM 596_ VVAHQ 601_ YSFAP 606_ DGEAR 611_ LVSRC 616_ PADNP 621_ GLVQA 626_ QPRVP 631_ LTPTR 636_ GTSSR 641_ VAVQR 646_ GVGSG 651_ PHPPD 656_ TQQPS 661_ PSKAF 666_ KPRFP 671_ GDQVV 676_ NGAGP 681_ ELSTG 686_ PSPGS 691_ PTLDI 696_ DQSIE 701_ QLNRL 706_ ILELD 711_ PTFEP 716_ IPTHM 721_ NALGS 726_ QANGS 731_ VSPDS 736_ VGGGL 741_ RASSR 746_ LPDTG 751_ EGPSR 756_ ATGRQ 761_ GSSAE 766_ QPLGG 771_ RLRKL 776_ SLGQY 781_ DNDAG 786_ GQLPF 791_ SKCAW 796_ GKAGV 801_ DYAPN 806_ LPPFP 811_ SPADV 816_ KETMT 821_ PGYPQ 826_ DLDII 831_ DGRIL 836_ SSKES 841_ MCSTP 846_ AFPVS 851_ PETPY 856_ VKTAL 861_ RHPPF 866_ SPPEP 871_ PLSSP 876_ ASQHK 881_ GGREP 886_ RSCPE 891_ TLTHA 896_ VGMSE 901_ SPIGP 906_ KSTML 911_ RADAS 916_ STPSF 921_ QQAFA 926_ SSCTI 931_ SSNGP 936_ GQRRE 941_ SSSSA 946_ ERQWV 951_ ESSPK 956_ PMVSL 961_ LGSGR 966_ PTGSP 971_ LSAEF 976_ SGTRK 981_ DSPVL 986_ SCFPP 991_ SELQA 996_ PFHSH 1001_ ELSLA 1006_ EPPDS 1011_ LAPPS 1016_ SQAFL 1021_ GFGTA 1026_ PVGSG 1031_ LPPEE 1036_ DLGAL 1041_ LANSH 1046_ GASPT 1051_ PSIPL 1056_ TATGA 1061_ ADNGF 1066_ LSHNF 1071_ LTVAP 1076_ GHSSH 1081_ HSPGL 1086_ QGQGV 1091_ TLPGQ 1096_ PPLPE 1101_ KKRAS 1106_ EGDRS 1111_ LGSVS 1116_ PSSSG 1121_ FSSPH 1126_ SGSTI 1131_ SIPFP 1136_ NVLPD 1141_ FSKAS 1146_ EAASP 1151_ LPDSP 1156_ GDKLV 1161_ IVKFV 1166_ QDTSK 1171_ FWYKA 1176_ DISRE 1181_ QAIAM 1186_ LKDKE 1191_ PGSFI 1196_ VRDSH 1201_ SFRGA 1206_ YGLAM 1211_ KVATP 1216_ PPSVL 1221_ QLNKK 1226_ AGDLA 1231_ NELVR 1236_ HFLIE 1241_ CTPKG 1246_ VRLKG 1251_ CSNEP 1256_ YFGSL 1261_ TALVC 1266_ QHSIT 1271_ PLALP 1276_ CKLLI 1281_ PERDP 1286_ LEEIA 1291_ ESSPQ 1296_ TAANS 1301_ AAELL 1306_ KQGAA 1311_ CNVWY 1316_ LNSVE 1321_ MESLT 1326_ GHQAI 1331_ QKALS 1336_ ITLVQ 1341_ EPPPV 1346_ STVVH 1351_ FKVSA 1356_ QGITL 1361_ TDNQR 1366_ KLFFR 1371_ RHYPV 1376_ NSVIF 1381_ CALDP 1386_ QDRKW 1391_ IKDGP 1396_ SSKVF 1401_ GFVAR 1406_ KQGSA 1411_ TDNVC 1416_ HLFAE 1421_ HDPEQ 1426_ PASAI 1431_ VNFVS 1436_KVMIG
1: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841)