Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF)
1_MLWAL 6_ WPRWL 11_ ADKML 16_ PLLGA 21_ VLLQK 26_ REKRG 31_ PLWRH 36_ WRRET 41_ YPYYD 46_ LQVKV 51_ LRATN 56_ IRGTD 61_ LLSKA 66_ DCYVQ 71_ LWLPT 76_ ASPSP 81_ AQTRI 86_ VANCS 91_ DPEWN 96_ ETFHY 101_ QIHGA 106_ VKNVL 111_ ELTLY 116_ DKDIL 121_ GSDQL 126_ SLLLF 131_ DLRSL 136_ KCGQP 141_ HKHTF 146_ PLNHQ 151_ DSQEL 156_ QVEFV 161_ LEKSQ 166_ VPASE 171_ VITNG 176_ VLVAH 181_ PCLRI 186_ QGTLR 191_ GDGTA 196_ PREEY 201_ GSRQL 206_ QLAVP 211_ GAYEK 216_ PQLLP 221_ LQPPT 226_ EPGLP 231_ PTFTF 236_ HVNPV 241_ LSSRL 246_ HVELM 251_ ELLAA 256_ VQSGP 261_ SAELE 266_ AQTSK 271_ LGEGG 276_ ILLSS 281_ LPLGQ 286_ EEQCS 291_ VALGE 296_ GQEVA 301_ LSMKV 306_ EMSSG 311_ DLDLR 316_ LGFDL 321_ SDGEQ 326_ EFLDR 331_ RKQVV 336_ SKALQ 341_ QVLGL 346_ SEALD 351_ SGQVP 356_ VVAVL 361_ GSGGG 366_ TRAMS 371_ SLYGS 376_ LAGLQ 381_ ELGLL 386_ DTVTY 391_ LSGVS 396_ GSTWC 401_ ISTLY 406_ RDPAW 411_ SQVAL 416_ QGPIE 421_ RAQVH 426_ VCSSK 431_ MGALS 436_ TERLQ 441_ YYTQE 446_ LGVRE 451_ RSGHS 456_ VSLID 461_ LWGLL 466_ VEYLL 471_ YQEEN 476_ PAKLS 481_ DQQEA 486_ VRQGQ 491_ NPYPI 496_ YTSVN 501_ VRTNL 506_ SGEDF 511_ AEWCE 516_ FTPYE 521_ VGFPK 526_ YGAYV 531_ PTELF 536_ GSELF 541_ MGRLL 546_ QLQPE 551_ PRICY 556_ LQGMW 561_ GSAFA 566_ TSLDE 571_ IFLKT 576_ AGSGL 581_ SFLEW 586_ YRGSV 591_ NITDD 596_ CQKPQ 601_ LHNPS 606_ RLRTR 611_ LLTPQ 616_ GPFSQ 621_ AVLDI 626_ FTSRF 631_ TSAQS 636_ FNFTR 641_ GLCLH 646_ KDYVA 651_ GREFV 656_ AWKDT 661_ HPDAF 666_ PNQLT 671_ PMRDC 676_ LYLVD 681_ GGFAI 686_ NSPFP 691_ LALLP 696_ QRAVD 701_ LILSF 706_ DYSLE 711_ APFEV 716_ LKMTE 721_ KYCLD 726_ RGIPF 731_ PSIEV 736_ GPEDM 741_ EEARE 746_ CYLFA 751_ KAEDP 756_ RSPIV 761_ LHFPL 766_ VNRTF 771_ RTHLA 776_ PGVER 781_ QTAEE 786_ KAFGD 791_ FVINR 796_ PDTPY 801_ GMMNF 806_ TYEPQ 811_ DFYRL 816_ VALSR 821_ YNVLN 826_ NVETL 831_ KCALQ 836_ LALDR 841_HQARE
1: Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256)