Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)
1_MTMRS 6_ AVFKA 11_ AAAPA 16_ GGNPE 21_ QRLDY 26_ ERAAA 31_ LGGPE 36_ DEPGA 41_ AEAHF 46_ LPRHR 51_ KLKEP 56_ GPPLA 61_ SSQGG 66_ SPAPS 71_ PAGCG 76_ GKGRG 81_ LLLPA 86_ GAAPG 91_ QQEES 96_ WGGSV 101_ PLPCP 106_ PPATK 111_ QAGIG 116_ GEPAA 121_ AGAGC 126_ SPRPK 131_ YQAVL 136_ PIQTG 141_ SLVAA 146_ AKEPT 151_ PWAGD 156_ KGGAA 161_ SPAAT 166_ ASDPA 171_ GPPPL 176_ PLPGP 181_ PPLAP 186_ TATAG 191_ TLAAS 196_ EGRWK 201_ SMRKS 206_ PLGGG 211_ GGSGA 216_ SSQAA 221_ CLKQI 226_ LLLQL 231_ DLIEQ 236_ QQQQL 241_ QAKEK 246_ EIEEL 251_ KSERD 256_ TLLAR 261_ IERME 266_ RRMQL 271_ VKKDN 276_ EKERH 281_ KLFQG 286_ YETEE 291_ REETE 296_ LSEKI 301_ KLECQ 306_ PELSE 311_ TSQTL 316_ PPKPF 321_ SCGRS 326_ GKGHK 331_ RKSPF 336_ GSTER 341_ KTPVK 346_ KLAPE 351_ FSKVK 356_ TKTPK 361_ HSPIK 366_ EEPCG 371_ SLSET 376_ VCKRE 381_ LRSQE 386_ TPEKP 391_ RSSVD 396_ TPPRL 401_ STPQK 406_ GPSTH 411_ PKEKA 416_ FSSEI 421_ EDLPY 426_ LSTTE 431_ MYLCR 436_ WHQPP 441_ PSPLP 446_ LRESS 451_ PKKEE 456_ TVARC 461_ LMPSS 466_ VAGET 471_ SVLAV 476_ PSWRD 481_ HSVEP 486_ LRDPN 491_ PSDLL 496_ ENLDD 501_ SVFSK 506_ RHAKL 511_ ELDEK 516_ RRKRW 521_ DIQRI 526_ REQRI 531_ LQRLQ 536_ LRMYK 541_ KKGIQ 546_ ESEPE 551_ VTSFF 556_ PEPDD 561_ VESLM 566_ ITPFL 571_ PVVAF 576_ GRPLP 581_ KLTPQ 586_ NFELP 591_ WLDER 596_ SRCRL 601_ EIQKK 606_QTPHR
1: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816)