E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
1_MSGGH 6_ QLQLA 11_ ALWPW 16_ LLMAT 21_ LQAGF 26_ GRTGL 31_ VLAAA 36_ VESER 41_ SAEQK 46_ AIIRV 51_ IPLKM 56_ DPTGK 61_ LNLTL 66_ EGVFA 71_ GVAEI 76_ TPAEG 81_ KLMQS 86_ HPLYL 91_ CNASD 96_ DDNLE 101_ PGFIS 106_ IVKLE 111_ SPRRA 116_ PRPCL 121_ SLASK 126_ ARMAG 131_ ERGAS 136_ AVLFD 141_ ITEDR 146_ AAAEQ 151_ LQQPL 156_ GLTWP 161_ VVLIW 166_ GNDAE 171_ KLMEF 176_ VYKNQ 181_ KAHVR 186_ IELKE 191_ PPAWP 196_ DYDVW 201_ ILMTV 206_ VGTIF 211_ VIILA 216_ SVLRI 221_ RCRPR 226_ HSRPD 231_ PLQQR 236_ TAWAI 241_ SQLAT 246_ RRYQA 251_ SCRQA 256_ RGEWP 261_ DSGSS 266_ CSSAP 271_ VCAIC 276_ LEEFS 281_ EGQEL 286_ RVISC 291_ LHEFH 296_ RNCVD 301_ PWLHQ 306_ HRTCP 311_ LCMFN 316_ ITEGD 321_ SFSQS 326_ LGPSR 331_ SYQEP 336_ GRRLH 341_ LIRQH 346_ PGHAH 351_ YHLPA 356_ AYLLG 361_ PSRSA 366_ VARPP 371_ RPGPF 376_ LPSQE 381_ PGMGP 386_ RHHRF 391_ PRAAH 396_ PRAPG 401_ EQQRL 406_ AGAQH 411_ PYAQG 416_ WGLSH 421_ LQSTS 426_ QHPAA 431_ CPVPL 436_ RRARP 441_ PDSSG 446_ SGESY 451_ CTERS 456_ GYLAD 461_ GPASD 466_ SSSGP 471_ CHGSS 476_ SDSVV 481_ NCTDI 486_ SLQGV 491_ HGSSS 496_ TFCSS 501_ LSSDF 506_ DPLVY 511_ CSPKG 516_ DPQRV 521_ DMQPS 526_ VTSRP 531_ RSLDS 536_ VVPTG 541_ ETQVS 546_ SHVHY 551_ HRHRH 556_ HHYKK 561_ RFQWH 566_ GRKPG 571_ PETGV 576_ PQSRP 581_ PIPRT 586_ QPQPE 591_ PPSPD 596_ QQVTR 601_ SNSAA 606_ PSGRL 611_ SNPQC 616_ PRALP 621_ EPAPG 626_ PVDAS 631_ SICPS 636_ TSSLF 641_ NLQKS 646_ SLSAR 651_ HPQRK 656_ RRGGP 661_ SEPTP 666_ GSRPQ 671_ DATVH 676_ PACQI 681_ FPHYT 686_ PSVAY 691_ PWSPE 696_ AHPLI 701_ CGPPG 706_ LDKRL 711_ LPETP 716_ GPCYS 721_ NSQPV 726_ WLCLT 731_ PRQPL 736_ EPHPP 741_ GEGPS 746_ EWSSD 751_ TAEGR 756_ PCPYP 761_ HCQVL 766_ SAQPG 771_ SEEEL 776_EELCE
1: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)