Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
1_MKKQF 6_ NRMKQ 11_ LANQT 16_ VGRAE 21_ KTEVL 26_ SEDLL 31_ QIERR 36_ LDTVR 41_ SICHH 46_ SHKRL 51_ VACFQ 56_ GQHGT 61_ DAERR 66_ HKKLP 71_ LTALA 76_ QNMQE 81_ ASTQL 86_ EDSLL 91_ GKMLE 96_ TCGDA 101_ ENQLA 106_ LELSQ 111_ HEVFV 116_ EKEIV 121_ DPLYG 126_ IAEVE 131_ IPNIQ 136_ KQRKQ 141_ LARLV 146_ LDWDS 151_ VRARW 156_ NQAHK 161_ SSGTN 166_ FQGLP 171_ SKIDT 176_ LKEEM 181_ DEAGN 186_ KVEQC 191_ KDQLA 196_ ADMYN 201_ FMAKE 206_ GEYGK 211_ FFVTL 216_ LEAQA 221_ DYHRK 226_ ALAVL 231_ EKTLP 236_ EMRAH 241_ QDKWA 246_ EKPAF 251_ GTPLE 256_ EHLKR 261_ SGREI 266_ ALPIE 271_ ACVML 276_ LLETG 281_ MKEEG 286_ LFRIG 291_ AGASK 296_ LKKLK 301_ AALDC 306_ STSHL 311_ DEFYS 316_ DPHAV 321_ AGALK 326_ SYLRE 331_ LPEPL 336_ MTFNL 341_ YEEWT 346_ QVASV 351_ QDQDK 356_ KLQDL 361_ WRTCQ 366_ KLPPQ 371_ NFVNF 376_ RYLIK 381_ FLAKL 386_ AQTSD 391_ VNKMT 396_ PSNIA 401_ IVLGP 406_ NLLWA 411_ RNEGT 416_ LAEMA 421_ AATSV 426_ HVVAV 431_ IEPII 436_ QHADW 441_ FFPEE 446_ VEFNV 451_ SEAFV 456_ PLTTP 461_ SSNHS 466_ FHTGN 471_ DSDSG 476_ TLERK 481_ RPASM 486_ AVMEG 491_ DLVKK 496_ ESFGV 501_ KLMDF 506_ QAHRR 511_ GGTLN 516_ RKHIS 521_ PAFQP 526_ PLPPT 531_ DGSTV 536_ VPAGP 541_ EPPPQ 546_ SSRAE 551_ SSSGG 556_ GTVPS 561_ SAGIL 566_ EQGPS 571_ PGDGS 576_ PPKPK 581_ DPVSA 586_ AVPAP 591_ GRNNS 596_ QIASG 601_ QNQPQ 606_ AAAGS 611_ HQLSM 616_ GQPHN 621_ AAGPS 626_ PHTLR 631_ RAVKK 636_ PAPAP 641_ PKPGN 646_ PPPGH 651_ PGGQS 656_ SSGTS 661_ QHPPS 666_ LSPKP 671_ PTRSP 676_ SPPTQ 681_ HTGQP 686_ PGQPS 691_ APSQL 696_ SAPRR 701_ YSSSL 706_ SPIQA 711_ PNHPP 716_ PQPPT 721_ QATPL 726_ MHTKP 731_ NSQGP 736_ PNPMA 741_ LPSEH 746_ GLEQP 751_ SHTPP 756_ QTPTP 761_ PSTPP 766_ LGKQN 771_ PSLPA 776_ PQTLA 781_ GGNPE 786_ TAQPH 791_ AGTLP 796_ RPRPV 801_ PKPRN 806_ RPSVP 811_ PPPQP 816_ PGVHS 821_ AGDSS 826_ LTNTA 831_ PTASK 836_ IVTDS 841_ NSRVS 846_ EPHRS 851_ IFPEM 856_ HSDSA 861_ SKDVP 866_ GRILL 871_ DIDND 876_TESTA
1: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1