Dual specificity phosphatase 29 (Dual specificity phosphatase 27) (Dual specificity phosphatase DUPD1) (EC 3.1.3.16) (EC 3.1.3.48)
1_MTSGE 6_ VKTSL 11_ KNAYS 16_ SAKRL 21_ SPKME 26_ EEGEE 31_ EDYCT 36_ PGAFE 41_ LERLF 46_ WKGSP 51_ QYTHV 56_ NEVWP 61_ KLYIG 66_ DEATA 71_ LDRYR 76_ LQKAG 81_ FTHVL 86_ NAAHG 91_ RWNVD 96_ TGPDY 101_ YRDMD 106_ IQYHG 111_ VEADD 116_ LPTFD 121_ LSVFF 126_ YPAAA 131_ FIDRA 136_ LSDDH 141_ SKILV 146_ HCVMG 151_ RSRSA 156_ TLVLA 161_ YLMIH 166_ KDMTL 171_ VDAIQ 176_ QVAKN 181_ RCVLP 186_ NRGFL 191_ KQLRE 196_ LDKQL 201_ VQQRR 206_ RSQRQ 211_DGEEE
1: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (PubMed:17498703). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity)