Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)
1_MNPSE 6_ MQRKA 11_ PPRRR 16_ RHRNR 21_ APLTH 26_ KMNKM 31_ VTSEE 36_ QMKLP 41_ STKKA 46_ EPPTW 51_ AQLKK 56_ LTQLA 61_ TKYLE 66_ NTKVT 71_ QTPES 76_ MLLAA 81_ LMIVS 86_ MVSAG 91_ VPNSS 96_EETAT
1: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts