Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)
1_MALQM 6_ FVTYS 11_ PWNCL 16_ LLLVA 21_ LECSE 26_ ASSDL 31_ NESAN 36_ STAQY 41_ ASNAW 46_ FAAAS 51_ SEPEE 56_ GISVF 61_ ELDYD 66_ YVQIP 71_ YEVTL 76_ WILLA 81_ SLAKI 86_ GFHLY 91_ HRLPG 96_ LMPES 101_ CLLIL 106_ VGALV 111_ GGIIF 116_ GTDHK 121_ SPPVM 126_ DSSIY 131_ FLYLL 136_ PPIVL 141_ EGGYF 146_ MPTRP 151_ FFENI 156_ GSILW 161_ WAVLG 166_ ALINA 171_ LGIGL 176_ SLYLI 181_ CQVKA 186_ FGLGD 191_ VNLLQ 196_ NLLFG 201_ SLISA 206_ VDPVA 211_ VLAVF 216_ EEARV 221_ NEQLY 226_ MMIFG 231_ EALLN 236_ DGITV 241_ VLYNM 246_ LIAFT 251_ KMHKF 256_ EDIET 261_ VDILA 266_ GCARF 271_ IVVGL 276_ GGVLF 281_ GIVFG 286_ FISAF 291_ ITRFT 296_ QNISA 301_ IEPLI 306_ VFMFS 311_ YLSYL 316_ AAETL 321_ YLSGI 326_ LAITA 331_ CAVTM 336_ KKYVE 341_ ENVSQ 346_ TSYTT 351_ IKYFM 356_ KMLSS 361_ VSETL 366_ IFIFM 371_ GVSTV 376_ GKNHE 381_ WNWAF 386_ ICFTL 391_ AFCQI 396_ WRAIS 401_ VFALF 406_ YISNQ 411_ FRTFP 416_ FSIKD 421_ QCIIF 426_ YSGVR 431_ GAGSF 436_ SLAFL 441_ LPLSL 446_ FPRKK 451_ MFVTA 456_ TLVVI 461_ YFTVF 466_ IQGIT 471_ VGPLV 476_ RYLDV 481_ KKTNK 486_ KESIN 491_ EELHI 496_ RLMDH 501_ LKAGI 506_ EDVCG 511_ HWSHY 516_ QVRDK 521_ FKKFD 526_ HRYLR 531_ KILIR 536_ KNLPK 541_ SSIVS 546_ LYKKL 551_ EMKQA 556_ IEMVE 561_ TGILS 566_ STAFS 571_ IPHQA 576_ QRIQG 581_ IKRLS 586_ PEDVE 591_ SIRDI 596_ LTSNM 601_ YQVRQ 606_ RTLSY 611_ NKYNL 616_ KPQTS 621_ EKQAK 626_ EILIR 631_ RQNTL 636_ RESMR 641_ KGHSL 646_ PWGKP 651_ AGTKN 656_ IRYLS 661_ YPYGN 666_ PQSAG 671_ RDTRA 676_ AGFSD 681_ DDSSD 686_ PGSPS 691_ ITFSA 696_ CSRIG 701_ SLQKQ 706_ EAQEI 711_ IPMKS 716_ LHRGR 721_ KAFSF 726_ GYQRN 731_ TSQEE 736_ YLGGV 741_ RRVAL 746_ RPKPL 751_ FHAVD 756_ EEGES 761_ GGESE 766_ GKASL 771_ VEVRS 776_ RWTAD 781_ HGHGR 786_ DHHRS 791_HSPLL
1: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity)