Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D)
1_METMK 6_ SKANC 11_ AQNPN 16_ CNIMI 21_ FHPTK 26_ EEFND 31_ FDKYI 36_ AYMES 41_ QGAHR 46_ AGLAK 51_ IIPPK 56_ EWKAR 61_ ETYDN 66_ ISEIL 71_ IATPL 76_ QQVAS 81_ GRAGV 86_ FTQYH 91_ KKKKA 96_ MTVGE 101_ YRHLA 106_ NSKKY 111_ QTPPH 116_ QNFED 121_ LERKY 126_ WKNRI 131_ YNSPI 136_ YGADI 141_ SGSLF 146_ DENTK 151_ QWNLG 156_ HLGTI 161_ QDLLE 166_ KECGV 171_ VIEGV 176_ NTPYL 181_ YFGMW 186_ KTTFA 191_ WHTED 196_ MDLYS 201_ INYLH 206_ LGEPK 211_ TWYVV 216_ PPEHG 221_ QRLER 226_ LAREL 231_ FPGSS 236_ RGCGA 241_ FLRHK 246_ VALIS 251_ PTVLK 256_ ENGIP 261_ FNRIT 266_ QEAGE 271_ FMVTF 276_ PYGYH 281_ AGFNH 286_ GFNCA 291_ EAINF 296_ ATPRW 301_ IDYGK 306_ MASQC 311_ SCGEA 316_ RVTFS 321_ MDAFV 326_ RILQP 331_ ERYDL 336_ WKRGQ 341_ DRAVV 346_ DHMEP 351_ RVPAS 356_ QELST 361_ QKEVQ 366_ LPRRA 371_ ALGLR 376_ QLPSH 381_ WARHS 386_ PWPMA 391_ ARSGT 396_ RCHTL 401_ VCSSL 406_ PRRSA 411_ VSGTA 416_ TQPRA 421_ AAVHS 426_ SKKPS 431_ STPSS 436_ TPGPS 441_ AQIIH 446_ PSNGR 451_ RGRGR 456_ PPQKL 461_ RAQEL 466_ TLQTP 471_ AKRPL 476_ LAGTT 481_ CTASG 486_ PEPEP 491_ LPEDG 496_ ALMDK 501_ PVPLS 506_ PGLQH 511_ PVKAS 516_GCSWA
1: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate