NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)
1_MNSRR 6_ REPIT 11_ LQDPE 16_ AKYPL 21_ PLIEK 26_ EKISH 31_ NTRRF 36_ RFGLP 41_ SPDHV 46_ LGLPV 51_ GNYVQ 56_ LLAKI 61_ DNELV 66_ VRAYT 71_ PVSSD 76_ DDRGF 81_ VDLII 86_ KIYFK 91_ NVHPQ 96_ YPEGG 101_ KMTQY 106_ LENMK 111_ IGETI 116_ FFRGP 121_ RGRLF 126_ YHGPG 131_ NLGIR 136_ PDQTS 141_ EPKKT 146_ LADHL 151_ GMIAG 156_ GTGIT 161_ PMLQL 166_ IRHIT 171_ KDPSD 176_ RTRMS 181_ LIFAN 186_ QTEED 191_ ILVRK 196_ ELEEI 201_ ARTHP 206_ DQFNL 211_ WYTLD 216_ RPPIG 221_ WKYSS 226_ GFVTA 231_ DMIKE 236_ HLPPP 241_ AKSTL 246_ ILVCG 251_ PPPLI 256_ QTAAH 261_ PNLEK 266_ LGYTQ 271_DMIFT
1: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)