Atlastin-3 (EC 3.6.5.-)
1_MLSPQ 6_ RVAAA 11_ ASRGA 16_ DDAME 21_ SSKPG 26_ PVQVV 31_ LVQKD 36_ QHSFE 41_ LDEKA 46_ LASIL 51_ LQDHI 56_ RDLDV 61_ VVVSV 66_ AGAFR 71_ KGKSF 76_ ILDFM 81_ LRYLY 86_ SQKES 91_ GHSNW 96_ LGDPE 101_ EPLTG 106_ FSWRG 111_ GSDPE 116_ TTGIQ 121_ IWSEV 126_ FTVEK 131_ PGGKK 136_ VAVVL 141_ MDTQG 146_ AFDSQ 151_ STVKD 156_ CATIF 161_ ALSTM 166_ TSSVQ 171_ IYNLS 176_ QNIQE 181_ DDLQQ 186_ LQLFT 191_ EYGRL 196_ AMDEI 201_ FQKPF 206_ QTLMF 211_ LVRDW 216_ SFPYE 221_ YSYGL 226_ QGGMA 231_ FLDKR 236_ LQVKE 241_ HQHEE 246_ IQNVR 251_ NHIHS 256_ CFSDV 261_ TCFLL 266_ PHPGL 271_ QVATS 276_ PDFDG 281_ KLKDI 286_ AGEFK 291_ EQLQA 296_ LIPYV 301_ LNPSK 306_ LMEKE 311_ INGSK 316_ VTCRG 321_ LLEYF 326_ KAYIK 331_ IYQGE 336_ DLPHP 341_ KSMLQ 346_ ATAEA 351_ NNLAA 356_ AASAK 361_ DIYYN 366_ NMEEV 371_ CGGEK 376_ PYLSP 381_ DILEE 386_ KHCEF 391_ KQLAL 396_ DHFKK 401_ TKKMG 406_ GKDFS 411_ FRYQQ 416_ ELEEE 421_ IKELY 426_ ENFCK 431_ HNGSK 436_ NVFST 441_ FRTPA 446_ VLFTG 451_ IVALY 456_ IASGL 461_ TGFIG 466_ LEVVA 471_ QLFNC 476_ MVGLL 481_ LIALL 486_ TWGYI 491_ RYSGQ 496_ YRELG 501_ GAIDF 506_ GAAYV 511_ LEQAS 516_ SHIGN 521_ STQAT 526_ VRDAV 531_ VGRPS 536_MDKKA
1: Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:24459106, PubMed:27619977, PubMed:37102997). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)