Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)
1_MATVI 6_ PGDLS 11_ EVRDT 16_ QKVPS 21_ GKRKR 26_ GETKP 31_ RKNFP 36_ CQLCD 41_ KAFNS 46_ VEKLK 51_ VHSYS 56_ HTGER 61_ PYKCI 66_ QQDCT 71_ KAFVS 76_ KYKLQ 81_ RHMAT 86_ HSPEK 91_ THKCN 96_ YCEKM 101_ FHRKD 106_ HLKNH 111_ LHTHD 116_ PNKET 121_ FKCEE 126_ CGKNY 131_ NTKLG 136_ FKRHL 141_ ALHAA 146_ TSGDL 151_ TCKVC 156_ LQTFE 161_ STGVL 166_ LEHLK 171_ SHAGK 176_ SSGGV 181_ KEKKH 186_ QCEHC 191_ DRRFY 196_ TRKDV 201_ RRHMV 206_ VHTGR 211_ KDFLC 216_ QYCAQ 221_ RFGRK 226_ DHLTR 231_ HMKKS 236_ HNQEL 241_ LKVKT 246_ EPVDF 251_ LDPFT 256_ CNVSV 261_ PIKDE 266_ LLPVM 271_ SLPSS 276_ ELLSK 281_ PFTNT 286_ LQLNL 291_ YNTPF 296_ QSMQS 301_ SGSAH 306_ QMITT 311_ LPLGM 316_ TCPID 321_ MDTVH 326_ PSHHL 331_ SFKYP 336_ FSSTS 341_ YAISI 346_ PEKEQ 351_ PLKGE 356_ IESYL 361_ MELQG 366_ GVPSS 371_ SQDSQ 376_ ASSSS 381_ KLGLD 386_ PQIGS 391_ LDDGA 396_ GDLSL 401_ SKSSI 406_ SISDP 411_ LNTPA 416_ LDFSQ 421_ LFNFI 426_ PLNGP 431_ PYNPL 436_ SVGSL 441_ GMSYS 446_ QEEAH 451_ SSVSQ 456_ LPPQT 461_ QDLQD 466_ PANTI 471_ GLGSL 476_ HSLSA 481_ AFTSS 486_ LSTST 491_TLPRF
1: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia