IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)
1_MWCLH 6_ CNSER 11_ TQSLL 16_ ELELD 21_ SGVEG 26_ EAPSS 31_ ETGTS 36_ LDSPS 41_ AYPQG 46_ PLVPG 51_ SSLSP 56_ DHYEH 61_ TSVGA 66_ YGLYS 71_ GPPGQ 76_ QQRTR 81_ RPKLQ 86_ HSTSI 91_ LRKQA 96_ EEEAI 101_ KRSRS 106_ LSESY 111_ ELSSD 116_ LQDKQ 121_ VEMLE 126_ RKYGG 131_ RLVTR 136_ HAART 141_ IQTAF 146_ RQYQM 151_ NKNFE 156_ RLRSS 161_ MSENR 166_ MSRRI 171_ VLSNM 176_ RMQFS 181_ FEGPE 186_ KVHSS 191_ YFEGK 196_ QVSVT 201_ NDGSQ 206_ LGALV 211_ SPECG 216_ DLSEP 221_ TTLKS 226_ PAPSS 231_ DFADA 236_ ITELE 241_ DAFSR 246_ QVKSL 251_ AESID 256_ DALNC 261_ RSLHT 266_ EEAPA 271_ LDAAR 276_ ARDTE 281_ PQTAL 286_ HGMDH 291_ RKLDE 296_ MTASY 301_ SDVTL 306_ YIDEE 311_ ELSPP 316_ LPLSQ 321_ AGDRP 326_ SSTES 331_ DLRLR 336_ AGGAA 341_ PDYWA 346_ LAHKE 351_ DKADT 356_ DTSCR 361_ STPSL 366_ ERQEQ 371_ RLRVE 376_ HLPLL 381_ TIEPP 386_ SDSSV 391_ DLSDR 396_ SERGS 401_ LKRQS 406_ AYERS 411_ LGGQQ 416_ GSPKH 421_ GPHSG 426_ APKSL 431_ PREEP 436_ ELRPR 441_ PPRPL 446_ DSHLA 451_ INGSA 456_ NRQSK 461_ SESDY 466_ SDGDN 471_ DSINS 476_ TSNSN 481_ DTINC 486_ SSESS 491_ SRDSL 496_ REQTL 501_ SKQTY 506_ HKEAR 511_ NSWDS 516_ PAFSN 521_ DVIRK 526_ RHYRI 531_ GLNLF 536_ NKKPE 541_ KGVQY 546_ LIERG 551_ FVPDT 556_ PVGVA 561_ HFLLQ 566_ RKGLS 571_ RQMIG 576_ EFLGN 581_ RQKQF 586_ NRDVL 591_ DCVVD 596_ EMDFS 601_ TMELD 606_ EALRK 611_ FQAHI 616_ RVQGE 621_ AQKVE 626_ RLIEA 631_ FSQRY 636_ CICNP 641_ GVVRQ 646_ FRNPD 651_ TIFIL 656_ AFAII 661_ LLNTD 666_ MYSPN 671_ VKPER 676_ KMKLE 681_ DFIKN 686_ LRGVD 691_ DGEDI 696_ PREML 701_ MGIYE 706_ RIRKR 711_ ELKTN 716_ EDHVS 721_ QVQKV 726_ EKLIV 731_ GKKPI 736_ GSLHP 741_ GLGCV 746_ LSLPH 751_ RRLVC 756_ YCRLF 761_ EVPDP 766_ NKPQK 771_ LGLHQ 776_ REIFL 781_ FNDLL 786_ VVTKI 791_ FQKKK 796_ NSVTY 801_ SFRQS 806_ FSLYG 811_ MQVLL 816_ FENQY 821_ YPNGI 826_ RLTSS 831_ VPGAD 836_ IKVLI 841_ NFNAP 846_ NPQDR 851_ KKFTD 856_ DLRES 861_ IAEVQ 866_ EMEKH 871_ RIESE 876_ LEKQK 881_ GVVRP 886_ SMSQC 891_ SSLKK 896_ ESGNG 901_ TLSRA 906_ CLDDS 911_ YASGE 916_ GLKRS 921_ ALSSS 926_ LRDLS 931_ EAGKR 936_ GRRSS 941_ AGSLE 946_ SNVEF 951_ QPFEP 956_LQPSV
1: Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity)