Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene)
1_MPEPA 6_ KFAPA 11_ PKKGS 16_ KKAVT 21_ KAQKK 26_ DGKKR 31_ KRSRK 36_ ESYSI 41_ YVYKV 46_ LKRVH 51_ PDTGI 56_ WCKAM 61_ GIMNS 66_ FLNDI 71_ FERIA 76_ GEASR 81_ LAHYN 86_ KRSTI 91_ TSRRS 96_ RRPCA 101_ CCCPA 106_ SWPST 111_ PCPRA 116_ PRRSP 121_ STPAP 126_ SESLP 131_ GPGAR 136_ SLPPS 141_ LPPRV 146_ AGCFV 151_ SKGSF 156_QGHLT
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling