Acyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS)
1_MLLPS 6_ KKDLK 11_ TALDV 16_ FAVFQ 21_ WSFSA 26_ LLITT 31_ TVIAV 36_ NLYLV 41_ VFTPY 46_ WPVTV 51_ LILTW 56_ LAFDW 61_ KTPQR 66_ GGRRF 71_ TCVRH 76_ WRLWK 81_ HYSDY 86_ FPLKL 91_ LKTHD 96_ ICPSR 101_ NYILV 106_ CHPHG 111_ LFAHG 116_ WFGHF 121_ ATEAS 126_ GFSKI 131_ FPGIT 136_ PYILT 141_ LGAFF 146_ WMPFL 151_ REYVM 156_ STGAC 161_ SVSRS 166_ SIDFL 171_ LTHKG 176_ TGNMV 181_ IVVIG 186_ GLAEC 191_ RYSLP 196_ GSSTL 201_ VLKNR 206_ SGFVR 211_ MALQH 216_ GVPLI 221_ PAYAF 226_ GETDL 231_ YDQHI 236_ FTPGG 241_ FVNRF 246_ QKWFQ 251_ SMVHI 256_ YPCAF 261_ YGRGF 266_ TKNSW 271_ GLLPY 276_ SRPVT 281_ TIVGE 286_ PLPMP 291_ KIENP 296_ SQEIV 301_ AKYHT 306_ LYIDA 311_ LRKLF 316_ DQHKT 321_ KFGIS 326_ETQEL
1: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687)