Gene name: IL31

Uniprot entry:

Q6EBC2

Protein names:

Interleukin-31 (IL-31)

Protein sequence:

1_MASHS 6_ GPSTS 11_ VLFLF 16_ CCLGG 21_ WLASH 26_ TLPVR 31_ LLRPS 36_ DDVQK 41_ IVEEL 46_ QSLSK 51_ MLLKD 56_ VEEEK 61_ GVLVS 66_ QNYTL 71_ PCLSP 76_ DAQPP 81_ NNIHS 86_ PAIRA 91_ YLKTI 96_ RQLDN 101_ KSVID 106_ EIIEH 111_ LDKLI 116_ FQDAP 121_ ETNIS 126_ VPTDT 131_ HECKR 136_ FILTI 141_ SQQFS 146_ ECMDL 151_ ALKSL 156_TSGAQ

Protein annotations

Protein functions:

1: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity)