Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
1_MANEK 6_ PTEEV 11_ KTENN 16_ NHINL 21_ KVAGQ 26_ DGSVV 31_ QFKIK 36_ RQTPL 41_ SKLMK 46_ AYCEP 51_ RGLSV 56_ KQIRF 61_ RFGGQ 66_ PISGT 71_ DKPAQ 76_ LEMED 81_ EDTID 86_VFQQP
1: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I