C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)
1_MMQEQ 6_ QPQST 11_ EKRGW 16_ LSLRL 21_ WSVAG 26_ ISIAL 31_ LSACF 36_ IVSCV 41_ VTYHF 46_ TYGET 51_ GKRLS 56_ ELHSY 61_ HSSLT 66_ CFSEG 71_ TKVPA 76_ WGCCP 81_ ASWKS 86_ FGSSC 91_ YFISS 96_ EEKVW 101_ SKSEQ 106_ NCVEM 111_ GAHLV 116_ VFNTE 121_ AEQNF 126_ IVQQL 131_ NESFS 136_ YFLGL 141_ SDPQG 146_ NNNWQ 151_ WIDKT 156_ PYEKN 161_ VRFWH 166_ LGEPN 171_ HSAEQ 176_ CASIV 181_ FWKPT 186_ GWGWN 191_ DVICE 196_ TRRNS 201_ICEMN
1: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity)