Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5)
1_MPIVM 6_ ARDLE 11_ ETASS 16_ SEDEE 21_ VISQE 26_ DHPCI 31_ MWTGG 36_ CRRIP 41_ VLVFH 46_ ADAIL 51_ TKDNN 56_ IRVIG 61_ ERYHL 66_ SYKIV 71_ RTDSR 76_ LVRSI 81_ LTAHG 86_ FHEVH 91_ PSSTD 96_ YNLMW 101_ TGSHL 106_ KPFLL 111_ RTLSE 116_ AQKVN 121_ HFPRS 126_ YELTR 131_ KDRLY 136_ KNIIR 141_ MQHTH 146_ GFKAF 151_ HILPQ 156_ TFLLP 161_ AEYAE 166_ FCNSY 171_ SKDRG 176_ PWIVK 181_ PVASS 186_ RGRGV 191_ YLINN 196_ PNQIS 201_ LEENI 206_ LVSRY 211_ INNPL 216_ LIDDF 221_ KFDVR 226_ LYVLV 231_ TSYDP 236_ LVIYL 241_ YEEGL 246_ ARFAT 251_ VRYDQ 256_ GAKNI 261_ RNQFM 266_ HLTNY 271_ SVNKK 276_ SGDYV 281_ SCDDP 286_ EVEDY 291_ GNKWS 296_ MSAML 301_ RYLKQ 306_ EGRDT 311_ TALMA 316_ HVEDL 321_ IIKTI 326_ ISAEL 331_ AIATA 336_ CKTFV 341_ PHRSS 346_ CFELY 351_ GFDVL 356_ IDSTL 361_ KPWLL 366_ EVNLS 371_ PSLAC 376_ DAPLD 381_ LKIKA 386_ SMISD 391_ MFTVV 396_ GFVCQ 401_ DPAQR 406_ ASTRP 411_ IYPTF 416_ ESSRR 421_ NPFQK 426_ PQRCR 431_ PLSAS 436_ DAEMK 441_ NLVGS 446_ AREKG 451_ PGKLG 456_ GSVLG 461_ LSMEE 466_ IKVLR 471_ RVKEE 476_ NDRRG 481_ GFIRI 486_ FPTSE 491_ TWEIY 496_ GSYLE 501_ HKTSM 506_ NYMLA 511_ TRLFQ 516_ DRMTA 521_ DGAPE 526_ LKIES 531_ LNSKA 536_ KLHAA 541_ LYERK 546_ LLSLE 551_ VRKRR 556_ RRSSR 561_ LRAMR 566_ PKYPV 571_ ITQPA 576_ EMNVK 581_ TETES 586_ EEEEE 591_ VALDN 596_ EDEEQ 601_ EASQE 606_ ESAGF 611_ LRENQ 616_ AKYTP 621_ SLTAL 626_ VENTP 631_ KENSM 636_ KVREW 641_ NNKGG 646_ HCCKL 651_ ETQEL 656_ EPKFN 661_ LMQIL 666_ QDNGN 671_ LSKMQ 676_ ARIAF 681_ SAYLQ 686_ HVQIR 691_ LMKDS 696_ GGQTF 701_ SASWA 706_ AKEDE 711_ QMELV 716_ VRFLK 721_ RASNN 726_ LQHSL 731_ RMVLP 736_ SRRLA 741_ LLERR 746_ RILAH 751_ QLGDF 756_ IIVYN 761_ KETEQ 766_ MAEKK 771_ SKKKV 776_ EEEEE 781_ DGVNM 786_ ENFQE 791_ FIRQA 796_ SEAEL 801_ EEVLT 806_ FYTQK 811_ NKSAS 816_ VFLGT 821_ HSKIS 826_ KNNNN 831_ YSDSG 836_ AKGDH 841_ PETIM 846_ EEVKI 851_ KPPKQ 856_ QQTTE 861_ IHSDK 866_ LSRFT 871_ TSAEK 876_ EAKLV 881_ YSNSS 886_ SGPTA 891_ TLQKI 896_ PNTHL 901_ SSVTT 906_ SDLSP 911_ GPCHH 916_ SSLSQ 921_ IPSAI 926_ PSMPH 931_ QPTIL 936_ LNTVS 941_ ASASP 946_ CLHPG 951_ AQNIP 956_ SPTGL 961_ PRCRS 966_ GSHTI 971_ GPFSS 976_ FQSAA 981_ HIYSQ 986_ KLSRP 991_ SSAKA 996_ GSCYL 1001_ NKHHS 1006_ GIAKT 1011_ QKEGE 1016_ DASLY 1021_ SKRYN 1026_ QSMVT 1031_ AELQR 1036_ LAEKQ 1041_ AARQY 1046_ SPSSH 1051_ INLLT 1056_ QQVTN 1061_ LNLAT 1066_ GIINR 1071_ SSASA 1076_ PPTLR 1081_ PIISP 1086_ SGPTW 1091_ STQSD 1096_ PQAPE 1101_ NHSSS 1106_ PGSRS 1111_ LQTGG 1116_ FAWEG 1121_ EVENN 1126_ VYSQA 1131_ TGVVP 1136_ QHKYH 1141_ PTAGS 1146_ YQLQF 1151_ ALQQL 1156_ EQQKL 1161_ QSRQL 1166_ LDQSR 1171_ ARHQA 1176_ IFGSQ 1181_ TLPNS 1186_ NLWTM 1191_ NNGAG 1196_ CRISS 1201_ ATASG 1206_ QKPTT 1211_ LPQKV 1216_ VPPPS 1221_ SCASL 1226_ VPKPP 1231_ PNHEQ 1236_ VLRRA 1241_ TSQKA 1246_ SKGSS 1251_ AEGQL 1256_ NGLQS 1261_ SLNPA 1266_ AFVPI 1271_ TSSTD 1276_PAHTK
1: Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (PubMed:22493317). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691)