Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)
1_MFLSI 6_ LVALC 11_ LWLHL 16_ ALGVR 21_ GAPCE 26_ AVRIP 31_ MCRHM 36_ PWNIT 41_ RMPNH 46_ LHHST 51_ QENAI 56_ LAIEQ 61_ YEELV 66_ DVNCS 71_ AVLRF 76_ FLCAM 81_ YAPIC 86_ TLEFL 91_ HDPIK 96_ PCKSV 101_ CQRAR 106_ DDCEP 111_ LMKMY 116_ NHSWP 121_ ESLAC 126_ DELPV 131_ YDRGV 136_ CISPE 141_ AIVTD 146_ LPEDV 151_ KWIDI 156_ TPDMM 161_ VQERP 166_ LDVDC 171_ KRLSP 176_ DRCKC 181_ KKVKP 186_ TLATY 191_ LSKNY 196_ SYVIH 201_ AKIKA 206_ VQRSG 211_ CNEVT 216_ TVVDV 221_ KEIFK 226_ SSSPI 231_ PRTQV 236_ PLITN 241_ SSCQC 246_ PHILP 251_ HQDVL 256_ IMCYE 261_ WRSRM 266_ MLLEN 271_ CLVEK 276_ WRDQL 281_ SKRSI 286_ QWEER 291_ LQEQR 296_ RTVQD 301_ KKKTA 306_ GRTSR 311_ SNPPK 316_ PKGKP 321_ PAPKP 326_ ASPKK 331_ NIKTR 336_ SAQKR 341_TNPKR
1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927)