Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)
1_MADFG 6_ ISAGQ 11_ FVAVV 16_ WDKSS 21_ PVEAL 26_ KGLVD 31_ KLQAL 36_ TGNEG 41_ RVSVE 46_ NIKQL 51_ LQSAH 56_ KESSF 61_ DIILS 66_ GLVPG 71_ STTLH 76_ SAEIL 81_ AEIAR 86_ ILRPG 91_ GCLFL 96_ KEPVE 101_ TAVDN 106_ NSKVK 111_ TASKL 116_ CSALT 121_ LSGLV 126_ EVKEL 131_ QREPL 136_ TPEEV 141_ QSVRE 146_ HLGHE 151_ SDNLL 156_ FVQIT 161_ GKKPN 166_ FEVGS 171_ SRQLK 176_ LSITK 181_ KSSPS 186_ VKPAV 191_ DPAAA 196_ KLWTL 201_ SANDM 206_ EDDSM 211_ DLIDS 216_ DELLD 221_ PEDLK 226_ KPDPA 231_ SLRAA 236_ SCGEG 241_ KKRKA 246_ CKNCT 251_ CGLAE 256_ ELEKE 261_ KSREQ 266_ MSSQP 271_ KSACG 276_ NCYLG 281_ DAFRC 286_ ASCPY 291_ LGMPA 296_ FKPGE 301_ KVLLS 306_DSNLH
1: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity)