Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2)
1_MAPSF 6_ TARIQ 11_ LFLLR 16_ ALGFL 21_ IGLVG 26_ RAALV 31_ LGGPK 36_ FASKT 41_ PRPVT 46_ EPLLL 51_ LSGMQ 56_ LAKLI 61_ RQRKV 66_ KCIDV 71_ VQAYI 76_ NRIKD 81_ VNPMI 86_ NGIVK 91_ YRFEE 96_ AMKEA 101_ HAVDQ 106_ KLAEK 111_ QEDEA 116_ TLENK 121_ WPFLG 126_ VPLTV 131_ KEAFQ 136_ LQGMP 141_ NSSGL 146_ MNRRD 151_ AIAKT 156_ DATVV 161_ ALLKG 166_ AGAIP 171_ LGITN 176_ CSELC 181_ MWYES 186_ SNKIY 191_ GRSNN 196_ PYDLQ 201_ HIVGG 206_ SSGGE 211_ GCTLA 216_ AACSV 221_ IGVGS 226_ DIGGS 231_ IRMPA 236_ FFNGI 241_ FGHKP 246_ SPGVV 251_ PNKGQ 256_ FPLAV 261_ GAQEL 266_ FLCTG 271_ PMCRY 276_ AEDLA 281_ PMLKV 286_ MAGPG 291_ IKRLK 296_ LDTKV 301_ HLKDL 306_ KFYWM 311_ EHDGG 316_ SFLMS 321_ KVDQD 326_ LIMTQ 331_ KKVVV 336_ HLETI 341_ LGASV 346_ QHVKL 351_ KKMKY 356_ SFQLW 361_ IAMMS 366_ AKGHD 371_ GKEPV 376_ KFVDL 381_ LGDHG 386_ KHVSP 391_ LWELI 396_ KWCLG 401_ LSVYT 406_ IPSIG 411_ LALLE 416_ EKLRY 421_ SNEKY 426_ QKFKA 431_ VEESL 436_ RKELV 441_ DMLGD 446_ DGVFL 451_ YPSHP 456_ TVAPK 461_ HHVPL 466_ TRPFN 471_ FAYTG 476_ VFSAL 481_ GLPVT 486_ QCPLG 491_ LNAKG 496_ LPLGI 501_ QVVAG 506_ PFNDH 511_ LTLAV 516_ AQYLE 521_ KTFGG 526_WVCPG
1: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates