XIAP-associated factor 1 (BIRC4-binding protein)
1_MEGDF 6_ SVCRN 11_ CKRHV 16_ VSANF 21_ TLHEA 26_ YCLRF 31_ LVLCP 36_ ECEEP 41_ VPKET 46_ MEEHC 51_ KLEHQ 56_ QVGCT 61_ MCQQS 66_ MQKSS 71_ LEFHK 76_ ANECQ 81_ ERPVE 86_ CKFCK 91_ LDMQL 96_ SKLEL 101_ HESYC 106_ GSRTE 111_ LCQGC 116_ GQFIM 121_ HRMLA 126_ QHRDV 131_ CRSEQ 136_ AQLGK 141_ GERIS 146_ APERE 151_ IYCHY 156_ CNQMI 161_ PENKY 166_ FHHMG 171_ KCCPD 176_ SEFKK 181_ HFPVG 186_ NPEIL 191_ PSSLP 196_ SQAAE 201_ NQTST 206_ MEKDV 211_ RPKTR 216_ SINRF 221_ PLHSE 226_ SSSKK 231_ APRSK 236_ NKTLD 241_ PLLMS 246_ EPKPR 251_ TSSPR 256_ GDKAA 261_ YDILR 266_ RCSQC 271_ GILLP 276_ LPILN 281_ QHQEK 286_ CRWLA 291_ SSKGK 296_QVRNF
1: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells