Gene name: ITPRIPL1

Uniprot entry:

Q6GPH6

Protein names:

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

Protein sequence:

1_MNVDA 6_ EASMA 11_ VISLL 16_ FLAVM 21_ YVVHH 26_ PLMVS 31_ DRMDL 36_ DTLAR 41_ SRQLE 46_ KRMSE 51_ EMRLL 56_ EMEFE 61_ ERKRA 66_ AEQRQ 71_ KAENF 76_ WTGDT 81_ SSDQL 86_ VLGKK 91_ DMGWP 96_ FQADG 101_ QEGPL 106_ GWMLG 111_ NLWNT 116_ GLFCL 121_ FLVFE 126_ LLRQN 131_ MQHEP 136_ AFDSS 141_ SEEEE 146_ EEVRV 151_ VPVTS 156_ YNWLT 161_ DFPSQ 166_ EALDS 171_ FYKHY 176_ VQNAI 181_ RDLPC 186_ TCEFV 191_ ESFVD 196_ DLIEA 201_ CRVLS 206_ RQEAH 211_ PQLED 216_ CLGIG 221_ AAFEK 226_ WGTLH 231_ ETQKF 236_ DILVP 241_ IVPPQ 246_ GTMFV 251_ LEMRD 256_ PALGR 261_ RCGCV 266_ LVESE 271_ CVCKR 276_ EKLLG 281_ DVLCL 286_ VHHHR 291_ DPSAV 296_ LGKCS 301_ SSIKA 306_ ALCTG 311_ FHLDV 316_ CKTVQ 321_ WFRNM 326_ MGNAW 331_ ALVAH 336_ KYDFK 341_ LSLPP 346_ STTSC 351_ KLRLD 356_ YRSGR 361_ FLSIH 366_ LVLGV 371_ QREDT 376_ LVYLV 381_ SQAPD 386_ QEQLT 391_ SVDWP 396_ ESFVA 401_ CEHLF 406_ LKLVG 411_ RFAPE 416_ NTCHL 421_ KCLQI 426_ ILSLR 431_ QHQSL 436_ PHGAS 441_ RPILT 446_ SYHFK 451_ TALMH 456_ LLLRL 461_ PLTDW 466_ AHNML 471_ SQRLQ 476_ DILWF 481_ LGRGL 486_ QQRSL 491_ HHFLI 496_ GNNFL 501_ PLTIP 506_ IPKTF 511_ RNAEP 516_ VNLFQ 521_ HLVLN 526_ PKAHS 531_ QAVEE 536_ FQNLL 541_ TQVKT 546_LPHAP

Protein annotations

Protein functions:

1: Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx