OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)
1_MTLDM 6_ DAVLS 11_ DFVRS 16_ TGAEP 21_ GLARD 26_ LLEGK 31_ NWDVN 36_ AALSD 41_ FEQLR 46_ QVHAG 51_ NLPPS 56_ FSEGS 61_ GGSRT 66_ PEKGF 71_ SDREP 76_ TRPPR 81_ PILQR 86_ QDDIV 91_ QEKRL 96_ SRGIS 101_ HASSS 106_ IVSLA 111_ RSHVS 116_ SNGGG 121_ GGSNE 126_ HPLEM 131_ PICAF 136_ QLPDL 141_ TVYNE 146_ DFRSF 151_ IERDL 156_ IEQSM 161_ LVALE 166_ QAGRL 171_ NWWVS 176_ VDPTS 181_ QRLLP 186_ LATTG 191_ DGNCL 196_ LHAAS 201_ LGMWG 206_ FHDRD 211_ LMLRK 216_ ALYAL 221_ MEKGV 226_ EKEAL 231_ KRRWR 236_ WQQTQ 241_ QNKES 246_ GLVYT 251_ EDEWQ 256_ KEWNE 261_ LIKLA 266_ SSEPR 271_ MHLGT 276_ NGANC 281_ GGVES 286_ SEEPV 291_ YESLE 296_ EFHVF 301_ VLAHV 306_ LRRPI 311_ VVVAD 316_ TMLRD 321_ SGGEA 326_ FAPIP 331_ FGGIY 336_ LPLEV 341_ PASQC 346_ HRSPL 351_ VLAYD 356_ QAHFS 361_ ALVSM 366_ EQKEN 371_ TKEQA 376_ VIPLT 381_ DSEYK 386_ LLPLH 391_ FAVDP 396_ GKGWE 401_ WGKDD 406_ SDNVR 411_ LASVI 416_ LSLEV 421_ KLHLL 426_ HSYMN 431_ VKWIP 436_ LSSDA 441_ QAPLA 446_ QPESP 451_ TASAG 456_ DEPRS 461_ TPESG 466_ DSDKE 471_ SVGSS 476_ STSNE 481_ GGRRK 486_ EKSKR 491_ DREKD 496_ KKRAD 501_ SVANK 506_ LGSFG 511_ KTLGS 516_ KLKKN 521_ MGGLM 526_ HSKGS 531_ KPGGV 536_ GTGLG 541_ GSSGT 546_ ETLEK 551_ KKKNS 556_ LKSWK 561_ GGKEE 566_ AAGDG 571_ PVSEK 576_ PPAES 581_ VGNGG 586_ SKYSQ 591_ EVMQS 596_ LSILR 601_ TAMQG 606_ EGKFI 611_ FVGTL 616_ KMGHR 621_ HQYQE 626_ EMIQR 631_ YLSDA 636_ EERFL 641_ AEQKQ 646_ KEAER 651_ KIMNG 656_ GIGGG 661_ PPPAK 666_ KPEPD 671_ AREEQ 676_ PTGPP 681_ AESRA 686_ MAFST 691_ GYPGD 696_ FTIPR 701_ PSGGG 706_ VHCQE 711_ PRRQL 716_ AGGPC 721_ VGGLP 726_ PYATF 731_ PRQCP 736_ PGRPY 741_ PHQDS 746_ IPSLE 751_ PGSHS 756_ KDGLH 761_ RGALL 766_ PPPYR 771_ VADSY 776_ SNGYR 781_ EPPEP 786_ DGWAG 791_ GLRGL 796_ PPTQT 801_ KCKQP 806_ NCSFY 811_ GHPET 816_ NNFCS 821_ CCYRE 826_ ELRRR 831_ EREPD 836_GELLV
1: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822)