N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1)
1_MAQRC 6_ VCVLA 11_ LVAML 16_ LLVFP 21_ TVSRS 26_ MGPRS 31_ GEHQR 36_ ASRIP 41_ SQFSK 46_ EERVA 51_ MKEAL 56_ KGAIQ 61_ IPTVT 66_ FSSEK 71_ SNTTA 76_ LAEFG 81_ KYIHK 86_ VFPTV 91_ VSTSF 96_ IQHEV 101_ VEEYS 106_ HLFTI 111_ QGSDP 116_ SLQPY 121_ LLMAH 126_ FDVVP 131_ APEEG 136_ WEVPP 141_ FSGLE 146_ RDGII 151_ YGRGT 156_ LDDKN 161_ SVMAL 166_ LQALE 171_ LLLIR 176_ KYIPR 181_ RSFFI 186_ SLGHD 191_ EESSG 196_ TGAQR 201_ ISALL 206_ QSRGV 211_ QLAFI 216_ VDEGG 221_ FILDD 226_ FIPNF 231_ KKPIA 236_ LIAVS 241_ EKGSM 246_ NLMLQ 251_ VNMTS 256_ GHSSA 261_ PPKET 266_ SIGIL 271_ AAAVS 276_ RLEQT 281_ PMPII 286_ FGSGT 291_ VVTVL 296_ QQLAN 301_ EFPFP 306_ VNIIL 311_ SNPWL 316_ FEPLI 321_ SRFME 326_ RNPLT 331_ NAIIR 336_ TTTAL 341_ TIFKA 346_ GVKFN 351_ VIPPV 356_ AQATV 361_ NFRIH 366_ PGQTV 371_ QEVLE 376_ LTKNI 381_ VADNR 386_ VQFHV 391_ LSAFD 396_ PLPVS 401_ PSDDK 406_ ALGYQ 411_ LLRQT 416_ VQSVF 421_ PEVNI 426_ TAPVT 431_ SIGNT 436_ DSRFF 441_ TNLTT 446_ GIYRF 451_ YPIYI 456_ QPEDF 461_ KRIHG 466_ VNEKI 471_ SVQAY 476_ ETQVK 481_ FIFEL 486_ IQNAD 491_ TDQEP 496_VSHLH
1: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase (PubMed:27374330). It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity)