Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)
1_MSPHP 6_ TALLG 11_ LVLCL 16_ AQTIH 21_ TQEED 26_ LPRPS 31_ ISAEP 36_ GTVIP 41_ LGSHV 46_ TFVCR 51_ GPVGV 56_ QTFRL 61_ ERDSR 66_ STYND 71_ TEDVS 76_ QASPS 81_ ESEAR 86_ FRIDS 91_ VREGN 96_ AGLYR 101_ CIYYK 106_ PPKWS 111_ EQSDY 116_ LELLV 121_ KESSG 126_ GPDSP 131_ DTEPG 136_ SSAGP 141_ TQRPS 146_ DNSHN 151_ EHAPA 156_ SQGLK 161_ AEHLY 166_ ILIGV 171_ SVVFL 176_ FCLLL 181_ LVLFC 186_ LHRQN 191_ QIKQG 196_ PPRSK 201_ DEEQK 206_ PQQRP 211_ DLAVD 216_ VLERT 221_ ADKAT 226_ VNGLP 231_ EKDRE 236_ TDTSA 241_ LAAGS 246_ SQEVT 251_ YAQLD 256_ HWALT 261_ QRTAR 266_ AVSPQ 271_ STKPM 276_ AESIT 281_YAAVA
1: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells