Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase)
1_MEGVG 6_ GLWPW 11_ VLGLL 16_ SLPGV 21_ ILGAP 26_ LASSC 31_ AGACG 36_ TSFPD 41_ GLTPE 46_ GTQAS 51_ GDKDI 56_ PAINQ 61_ GLILE 66_ ETPES 71_ SFLIE 76_ GDIIR 81_ PSPFR 86_ LLSAT 91_ SNKWP 96_ MGGSG 101_ VVEVP 106_ FLLSS 111_ KYDEP 116_ SRQVI 121_ LEALA 126_ EFERS 131_ TCIRF 136_ VTYQD 141_ QRDFI 146_ SIIPM 151_ YGCFS 156_ SVGRS 161_ GGMQV 166_ VSLAP 171_ TCLQK 176_ GRGIV 181_ LHELM 186_ HVLGF 191_ WHEHT 196_ RADRD 201_ RYIRV 206_ NWNEI 211_ LPGFE 216_ INFIK 221_ SQSSN 226_ MLTPY 231_ DYSSV 236_ MHYGR 241_ LAFSR 246_ RGLPT 251_ ITPLW 256_ APSVH 261_ IGQRW 266_ NLSAS 271_ DITRV 276_ LKLYG 281_ CSPSG 286_ PRPRG 291_ RGSHA 296_ HSTGR 301_ SPAPA 306_ SLSLQ 311_ RLLEA 316_ LSAES 321_ RSPDP 326_ SGSSA 331_ GGQPV 336_ PAGPG 341_ ESPHG 346_ WESPA 351_ LKKLS 356_ AEASA 361_ RQPQT 366_ LASSP 371_ RSRPG 376_ AGAPG 381_ VAQEQ 386_ SWLAG 391_ VSTKP 396_ TVPSS 401_ EAGIQ 406_ PVPVQ 411_ GSPAL 416_ PGGCV 421_ PRNHF 426_KGMSE
1: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding