THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)
1_MGAVT 6_ DDEVI 11_ RKRLL 16_ IDGDG 21_ AGDDR 26_ RINLL 31_ VKSFI 36_ KWCNS 41_ GSQEE 46_ GYSQY 51_ QRMLS 56_ TLSQC 61_ EFSMG 66_ KTLLV 71_ YDMNL 76_ REMEN 81_ YEKIY 86_ KEIEC 91_ SIAGA 96_ HEKIA 101_ ECKKQ 106_ ILQAK 111_ RIRKN 116_ RQEYD 121_ ALAKV 126_ IQHHP 131_ DRHET 136_ LKELE 141_ ALGKE 146_ LEHLS 151_ HIKES 156_ VEDKL 161_ ELRRK 166_ QFHVL 171_ LSTIH 176_ ELQQT 181_ LENDE 186_ KLSEV 191_ EEAQE 196_ASMET
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602)
2: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production