Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
1_MPGVC 6_ DRAPD 11_ FLSPS 16_ EDQVL 21_ RPALG 26_ SSVAL 31_ NCTAW 36_ VVSGP 41_ HCSLP 46_ SVQWL 51_ KDGLP 56_ LGIGG 61_ HYSLH 66_ EYSWV 71_ KANLS 76_ EVLVS 81_ SVLGV 86_ NVTST 91_ EVYGA 96_ FTCSI 101_ QNISF 106_ SSFTL 111_ QRAGP 116_ TSHVA 121_ AVLAS 126_ LLVLL 131_ ALLLA 136_ ALLYV 141_ KCRLN 146_ VLLWY 151_ QDAYG 156_ EVEIN 161_ DGKLY 166_ DAYVS 171_ YSDCP 176_ EDRKF 181_ VNFIL 186_ KPQLE 191_ RRRGY 196_ KLFLD 201_ DRDLL 206_ PRAEP 211_ SADLL 216_ VNLSR 221_ CRRLI 226_ VVLSD 231_ AFLSR 236_ AWCSH 241_ SFREG 246_ LCRLL 251_ ELTRR 256_ PIFIT 261_ FEGQR 266_ RDPAH 271_ PALRL 276_ LRQHR 281_ HLVTL 286_ LLWRP 291_ GSVTP 296_ SSDFW 301_ KEVQL 306_ ALPRK 311_ VQYRP 316_ VEGDP 321_ QTQLQ 326_ DDKDP 331_ MLILR 336_ GRVPE 341_ GRALD 346_ SEVDP 351_ DPEGD 356_ LGVRG 361_ PVFGE 366_ PSAPP 371_ HTSGV 376_ SLGES 381_ RSSEV 386_ DVSDL 391_ GSRNY 396_ SARTD 401_FYCLV
1: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP