Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Polyubiquitinated substrate transporter) (POST)
1_MEPPN 6_ LYPVK 11_ LYVYD 16_ LSKGL 21_ ARRLS 26_ PIMLG 31_ KQLEG 36_ IWHTS 41_ IVVHK 46_ DEFFF 51_ GSGGI 56_ SSCPP 61_ GGTLL 66_ GPPDS 71_ VVDVG 76_ STEVT 81_ EEIFL 86_ EYLSS 91_ LGESL 96_ FRGEA 101_ YNLFE 106_ HNCNT 111_ FSNEV 116_ AQFLT 121_ GRKIP 126_ SYITD 131_ LPSEV 136_ LSTPF 141_ GQALR 146_ PLLDS 151_ IQIQP 156_ PGGSS 161_VGRPN
1: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157)