Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)
1_MKRGR 6_ LPSSS 11_ EDSDD 16_ NGSLS 21_ TTWSQ 26_ NSRSQ 31_ HRRSS 36_ CSRHE 41_ DRKPS 46_ EVFRT 51_ DLITA 56_ MKLHD 61_ SYQLN 66_ PDEYY 71_ VLADP 76_ WRQEW 81_ EKGVQ 86_ VPVSP 91_ GTIPQ 96_ PVARV 101_ VSEEK 106_ SLMFI 111_ RPKKY 116_ IVSSG 121_ SEPPE 126_ LGYVD 131_ IRTLA 136_ DSVCR 141_ YDLND 146_ MDAAW 151_ LELTN 156_ EEFKE 161_ MGMPE 166_ LDEYT 171_ MERVL 176_ EEFEQ 181_ RCYDN 186_ MNHAI 191_ ETEEG 196_ LGIEY 201_ DEDVV 206_ CDVCQ 211_ SPDGE 216_ DGNEM 221_ VFCDK 226_ CNICV 231_ HQACY 236_ GILKV 241_ PEGSW 246_ LCRTC 251_ ALGVQ 256_ PKCLL 261_ CPKKG 266_ GAMKP 271_ TRSGT 276_ KWVHV 281_ SCALW 286_ IPEVS 291_ IGSPE 296_ KMEPI 301_ TKVSH 306_ IPSSR 311_ WALVC 316_ SLCNE 321_ KFGAS 326_ IQCSV 331_ KNCRT 336_ AFHVT 341_ CAFDR 346_ GLEMK 351_ TILAE 356_ NDEVK 361_ FKSYC 366_ PKHSS 371_ HRKPE 376_ ESLGK 381_ GAAQE 386_ NGAPE 391_ CSPRN 396_ PLEPF 401_ ASLEQ 406_ NREEA 411_ HRVSV 416_ RKQKL 421_ QQLED 426_ EFYTF 431_ VNLLD 436_ VARAL 441_ RLPEE 446_ VVDFL 451_ YQYWK 456_ LKRKV 461_ NFNKP 466_ LITPK 471_ KDEED 476_ NLAKR 481_ EQDVL 486_ FRRLQ 491_ LFTHL 496_ RQDLE 501_ RVRNL 506_ TYMVT 511_ RREKI 516_ KRSVC 521_ KVQEQ 526_ IFNLY 531_ TKLLE 536_ QERVS 541_ GVPSS 546_ CSSSS 551_ LENML 556_ LFNSP 561_ SVGPD 566_ APKIE 571_ DLKWH 576_ SAFFR 581_ KQMGT 586_ SLVHS 591_ LKKPH 596_ KRDPL 601_ QNSPG 606_ SEGKT 611_ LLKQP 616_ DLCGR 621_ REGMV 626_ VPESF 631_ LGLEK 636_ TFAEA 641_ RLISA 646_ QQKNG 651_ VVMPD 656_ HGKRR 661_ DNRFH 666_ CDLIK 671_ GDLKD 676_ KSFKQ 681_ SHKPL 686_ RSTDV 691_ SQRHL 696_ DNTRA 701_ ATSPG 706_ VGQSA 711_ PGTRK 716_ EIVPK 721_ CNGSL 726_ IKVNY 731_ NQTAV 736_ KVPTT 741_ PASPV 746_ KNWGG 751_ FRIPK 756_ KGERQ 761_ QQGEA 766_ HDGAC 771_ HQHSD 776_ YPYLG 781_ LGRVP 786_ AKERA 791_ KSKLK 796_ SDNEN 801_ DGYVP 806_ DVEMS 811_ DSESE 816_ ASEKK 821_ CIHTS 826_ STISR 831_ RTDII 836_RRSIL
1: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112)