Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)
1_MTDTR 6_ RRVKV 11_ YTLNE 16_ DRQWD 21_ DRGTG 26_ HVSSG 31_ YVERL 36_ KGMSL 41_ LVRAE 46_ SDGSL 51_ LLESK 56_ INPNT 61_ AYQKQ 66_ QDTLI 71_ VWSEA 76_ ENYDL 81_ ALSFQ 86_ EKAGC 91_ DEIWE 96_ KICQV 101_ QGKDP 106_ SVDIT 111_ QDLVD 116_ ESEEE 121_ RFDDM 126_ SSPGL 131_ ELPSC 136_ ELSRL 141_ EEIAE 146_ LVASS 151_ LPSPL 156_ RREKL 161_ ALALE 166_ NEGYI 171_ KKLLE 176_ LFHVC 181_ EDLEN 186_ IEGLH 191_ HLYEI 196_ IKGIF 201_ LLNRT 206_ ALFEV 211_ MFSEE 216_ CIMDV 221_ IGCLE 226_ YDPAL 231_ SQPRK 236_ HREFL 241_ TKTAK 246_ FKEVI 251_ PISDP 256_ ELKQK 261_ IHQTY 266_ RVQYI 271_ QDMVL 276_ PTPSV 281_ FEENM 286_ LSTLH 291_ SFIFF 296_ NKVEI 301_ VGMLQ 306_ EDEKF 311_ LTDLF 316_ AQLTD 321_ EATDE 326_ EKRQE 331_ LVNFL 336_ KEFCA 341_ FSQTL 346_ QPQNR 351_ DAFFK 356_ TLSNM 361_ GILPA 366_ LEVIL 371_ GMDDT 376_ QVRSA 381_ ATDIF 386_ SYLVE 391_ YNPSM 396_ VREFV 401_ MQEAQ 406_ QNDDV 411_ SKKLT 416_ EQKIT 421_ SKDIL 426_ LINLI 431_ IEHMI 436_ CDTDP 441_ ELGGA 446_ VQLMG 451_ LLRTL 456_ VDPEN 461_ MLATA 466_ NKTEK 471_ TEFLG 476_ FFYKH 481_ CMHVL 486_ TAPLL 491_ ANTTE 496_ DKPSK 501_ DDFQT 506_ AQLLA 511_ LVLEL 516_ LTFCV 521_ EHHTY 526_ HIKNY 531_ IINKD 536_ ILRRV 541_ LVLMA 546_ SKHAF 551_ LALCA 556_ LRFKR 561_ KIIGL 566_ KDEFY 571_ NRYIM 576_ KSFLF 581_ EPVVK 586_ AFLNN 591_ GSRYN 596_ LMNSA 601_ IIEMF 606_ EFIRV 611_ EDIKS 616_ LTAHV 621_ IENYW 626_ KALED 631_ VDYVQ 636_ TFKGL 641_ KLRFE 646_ QQRER 651_ QDNPK 656_ LDSMR 661_ SILRN 666_ HRYRR 671_ DARTL 676_ EDEEE 681_ MWFNT 686_ DEDDM 691_ EDGEA 696_ VVSPS 701_ DKTKN 706_ DDDIM 711_ DPISK 716_ FMERK 721_ KLKES 726_ EEKEV 731_ LLKTN 736_ LSGRQ 741_ SPSFK 746_ LSLSS 751_ GTKTN 756_ LTSQS 761_ STTNL 766_ PGSPG 771_ SPGSP 776_ GSPGS 781_ PGSVP 786_ KNTSQ 791_ TAAIT 796_ TKGGL 801_ VGLVD 806_ YPDDD 811_ EDDDE 816_ DEDKE 821_ DTLPL 826_SKKAK
1: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair