Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2)
1_MSREP 6_ TPPLP 11_ GDMST 16_ GPIAE 21_ SWCYT 26_ QVKVV 31_ KFSYM 36_ WTINN 41_ FSFCR 46_ EEMGE 51_ VLKSS 56_ TFSSG 61_ PSDKM 66_ KWCLR 71_ VNPKG 76_ LDDES 81_ KDYLS 86_ LYLLL 91_ VSCPK 96_ SEVRA 101_ KFKFS 106_ LLNAK 111_ REETK 116_ AMESQ 121_ RAYRF 126_ VQGKD 131_ WGFKK 136_ FIRRD 141_ FLLDE 146_ ANGLL 151_ PDDKL 156_ TLFCE 161_ VSVVQ 166_ DSVNI 171_ SGHTN 176_ TNTLK 181_ VPECR 186_ LAEDL 191_ GNLWE 196_ NTRFT 201_ DCSFF 206_ VRGQE 211_ FKAHK 216_ SVLAA 221_ RSPVF 226_ NAMFE 231_ HEMEE 236_ SKKNR 241_ VEIND 246_ LDPEV 251_ FKEMM 256_ RFIYT 261_ GRAPN 266_ LDKMA 271_ DNLLA 276_ AADKY 281_ ALERL 286_ KVMCE 291_ EALCS 296_ NLSVE 301_ NVADT 306_ LVLAD 311_ LHSAE 316_ QLKAQ 321_ AIDFI 326_ NRCSV 331_ LRQLG 336_ CKDGK 341_ NWNSN 346_ QATDI 351_ METSG 356_ WKSMI 361_ QSHPH 366_ LVAEA 371_ FRALA 376_ SAQCP 381_ QFGIP 386_RKRLK
1: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP