Centriole, cilia and spindle-associated protein
1_MSPGS 6_ GVKSE 11_ YMKRY 16_ QEPRW 21_ EEYGP 26_ CYREL 31_ LHYRL 36_ GRRLL 41_ EQAHA 46_ PWLWD 51_ DWGPA 56_ GSSED 61_ SASSE 66_ SSGAG 71_ GPAPR 76_ CAPPS 81_ PPPPV 86_ EPATQ 91_ EEAER 96_ RARGA 101_ PEEQD 106_ AEAGD 111_ AEAED 116_ AEDAA 121_ LPALP 126_ VKDVE 131_ DKPEQ 136_ QTRTR 141_ ETDKS 146_ PTSTE 151_ PRQQP 156_ SALFA 161_ RGNRK 166_ AVKSP 171_ QRSSS 176_ KIKEN 181_ KHPFA 186_ LYGWG 191_ EKQTD 196_ TGSQK 201_ THNVC 206_ ASAPV 211_ HEIHE 216_ SALRA 221_ KNRRQ 226_ VEKRK 231_ LVAQR 236_ QRAHS 241_ VDVEK 246_ NRKMK 251_ ASSSE 256_ NPWMT 261_EYMRC
1: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity)