N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)
1_MDENE 6_ SNQSL 11_ MTSSQ 16_ YPKEA 21_ VRKRQ 26_ NSARN 31_ SGASD 36_ SSRFS 41_ RKSFK 46_ LDYRL 51_ EEDVT 56_ KSKKG 61_ KDGRF 66_ VNPWP 71_ TWKNP 76_ SIPNV 81_ LRWLI 86_ MEKDH 91_ SSVPS 96_ SKEEL 101_ DKELP 106_ VLKPY 111_ FITNP 116_ EEAGV 121_ REAGL 126_ RVTWL 131_ GHATV 136_ MVEMD 141_ ELIFL 146_ TDPIF 151_ SSRAS 156_ PSQYM 161_ GPKRF 166_ RRSPC 171_ TISEL 176_ PPIDA 181_ VLISH 186_ NHYDH 191_ LDYNS 196_ VIALN 201_ ERFGN 206_ ELRWF 211_ VPLGL 216_ LDWMQ 221_ KCGCE 226_ NVIEL 231_ DWWEE 236_ NCVPG 241_ HDKVT 246_ FVFTP 251_ SQHWC 256_ KRTLM 261_ DDNKV 266_ LWGSW 271_ SVLGP 276_ WNRFF 281_ FAGDT 286_ GYCPA 291_ FEEIG 296_ KRFGP 301_ FDLAA 306_ IPIGA 311_ YEPRW 316_ FMKYQ 321_ HVDPE 326_ EAVRI 331_ HTDVQ 336_ TKKSM 341_ AIHWG 346_ TFALA 351_ NEHYL 356_ EPPVK 361_ LNEAL 366_ ERYGL 371_ NAEDF 376_ FVLKH 381_ GESRY 386_LNNDD
1: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:25684574, PubMed:27571266). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity)