Ras-related protein Rab-12
1_MDPGA 6_ ALQRR 11_ AGGGG 16_ GLGAG 21_ SPALS 26_ GGQGR 31_ RRKQP 36_ PRPAD 41_ FKLQV 46_ IIIGS 51_ RGVGK 56_ TSLME 61_ RFTDD 66_ TFCEA 71_ CKSTV 76_ GVDFK 81_ IKTVE 86_ LRGKK 91_ IRLQI 96_ WDTAG 101_ QERFN 106_ SITSA 111_ YYRSA 116_ KGIIL 121_ VYDIT 126_ KKETF 131_ DDLPK 136_ WMKMI 141_ DKYAS 146_ EDAEL 151_ LLVGN 156_ KLDCE 161_ TDREI 166_ TRQQG 171_ EKFAQ 176_ QITGM 181_ RFCEA 186_ SAKDN 191_ FNVDE 196_ IFLKL 201_ VDDIL 206_ KKMPL 211_ DILRN 216_ ELSNS 221_ ILSLQ 226_ PEPEI 231_ PPELP 236_PPRPH
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity)