Replication stress response regulator SDE2
1_MAEAA 6_ ALVWI 11_ RGPGF 16_ GCKAV 21_ RCASG 26_ RCTVR 31_ DFIHR 36_ HCQDQ 41_ NVPVE 46_ NFFVK 51_ CNGAL 56_ INTSD 61_ TVQHG 66_ AVYSL 71_ EPRLC 76_ GGKGG 81_ FGSML 86_ RALGA 91_ QIEKT 96_ TNREA 101_ CRDLS 106_ GRRLR 111_ DVNHE 116_ KAMAE 121_ WVKQQ 126_ AEREA 131_ EKEQK 136_ RLERL 141_ QRKLV 146_ EPKHC 151_ FTSPD 156_ YQQQC 161_ HEMAE 166_ RLEDS 171_ VLKGM 176_ QAASS 181_ KMVSA 186_ EISEN 191_ RKRQW 196_ PTKSQ 201_ TDRGA 206_ SAGKR 211_ RCFWL 216_ GMEGL 221_ ETAEG 226_ SNSES 231_ SDDDS 236_ EEAPS 241_ TSGMG 246_ FHAPK 251_ IGSNG 256_ VEMAA 261_ KFPSG 266_ SQRAR 271_ VVNTD 276_ HGSPE 281_ QLQIP 286_ VTDSG 291_ RHILE 296_ DSCAE 301_ LGESK 306_ EHMES 311_ RMVTE 316_ TEETQ 321_ EKKAE 326_ SKEPI 331_ EEEPT 336_ GAGLN 341_ KDKET 346_ EERTD 351_ GERVA 356_ EVAPE 361_ ERENV 366_ AVAKL 371_ QESQP 376_ GNAVI 381_ DKETI 386_ DLLAF 391_ TSVAE 396_ LELLG 401_ LEKLK 406_ CELMA 411_ LGLKC 416_ GGTLQ 421_ ERAAR 426_ LFSVR 431_ GLAKE 436_ QIDPA 441_ LFAKP 446_LKGKK
1: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959)
2: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity)
3: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507)